BNIP1 (BCL2 interacting protein 1)

2003-11-01  

Identity

HGNC
BNIP1
LOCATION
5q35.1
LOCUSID
662
ALIAS
NIP1,SEC20,TRG-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 662
MIM: 603291
HGNC: 1082
Ensembl: ENSG00000113734

Variants:

dbSNP: 662
ClinVar: 662
TCGA: ENSG00000113734
COSMIC: BNIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113734ENST00000231668Q12981
ENSG00000113734ENST00000351486Q12981
ENSG00000113734ENST00000352523Q12981
ENSG00000113734ENST00000393770Q12981
ENSG00000113734ENST00000519459H0YBK7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152723112004Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.42
219316932011RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.33
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
238961222013A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1.9
226390462012Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat.7
220209942012Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner.6
292220492018MTD-like motif of a BH3-only protein, BNIP1, induces necrosis accompanied by an intracellular calcium spike.0

Citation

Dessen P

BNIP1 (BCL2 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/820/bnip1-(bcl2-interacting-protein-1)