BRD1 (bromodomain containing 1)

2003-02-01  

Identity

HGNC
BRD1
LOCATION
22q13.33
LOCUSID
23774
ALIAS
BRL,BRPF1,BRPF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23774
MIM: 604589
HGNC: 1102
Ensembl: ENSG00000100425

Variants:

dbSNP: 23774
ClinVar: 23774
TCGA: ENSG00000100425
COSMIC: BRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100425ENST00000216267O95696
ENSG00000100425ENST00000216267A0A024R4W4
ENSG00000100425ENST00000404034O95696
ENSG00000100425ENST00000404034A0A024R4W4
ENSG00000100425ENST00000404760O95696
ENSG00000100425ENST00000404760A0A024R4V5
ENSG00000100425ENST00000438393J3KQ61
ENSG00000100425ENST00000457780O95696
ENSG00000100425ENST00000457780A0A024R4V5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359411072022The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.3
359411072022The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.3
335566232021Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.4
342593192021HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.20
344827742021Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.1
335566232021Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.4
342593192021HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.20
344827742021Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.1
294533162018BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.9
297945612018No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.0
300424002018Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.7
294533162018BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.9
297945612018No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.0
300424002018Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.7
280954952017DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.5

Citation

Dessen P

BRD1 (bromodomain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/835/brd1-(bromodomain-containing-1)