BRD1 (bromodomain containing 1)

2003-02-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
BRL,BRPF1,BRPF2
FUSION GENES

Other Information

Locus ID:

NCBI: 23774
MIM: 604589
HGNC: 1102
Ensembl: ENSG00000100425

Variants:

dbSNP: 23774
ClinVar: 23774
TCGA: ENSG00000100425
COSMIC: BRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100425ENST00000216267O95696
ENSG00000100425ENST00000216267A0A024R4W4
ENSG00000100425ENST00000404034O95696
ENSG00000100425ENST00000404034A0A024R4W4
ENSG00000100425ENST00000404760O95696
ENSG00000100425ENST00000404760A0A024R4V5
ENSG00000100425ENST00000438393J3KQ61
ENSG00000100425ENST00000457780O95696
ENSG00000100425ENST00000457780A0A024R4V5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359411072022The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.3
359411072022The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.3
335566232021Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.4
342593192021HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.20
344827742021Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.1
335566232021Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.4
342593192021HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.20
344827742021Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.1
294533162018BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.9
297945612018No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.0
300424002018Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.7
294533162018BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.9
297945612018No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.0
300424002018Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.7
280954952017DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.5

Citation

Dessen P

BRD1 (bromodomain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/835/brd1-(bromodomain-containing-1)