BRD2 (bromodomain containing 2)

2003-02-01  

Identity

HGNC
BRD2
LOCATION
6p21.32
LOCUSID
6046
ALIAS
BRD2-IT1,D6S113E,FSH,FSRG1,NAT,O27.1.1,RING3,RNF3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6046
MIM: 601540
HGNC: 1103
Ensembl: ENSG00000204256

Variants:

dbSNP: 6046
ClinVar: 6046
TCGA: ENSG00000204256
COSMIC: BRD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204256ENST00000374825P25440
ENSG00000204256ENST00000374825A0A024RCR5
ENSG00000204256ENST00000374831P25440
ENSG00000204256ENST00000374831A0A024RCR5
ENSG00000204256ENST00000395287P25440
ENSG00000204256ENST00000449025H0Y6K2
ENSG00000204256ENST00000449085P25440
ENSG00000204256ENST00000449085X5CF57
ENSG00000204256ENST00000456339H0Y799
ENSG00000204256ENST00000481259H0YDJ7
ENSG00000204256ENST00000482914E9PKQ9
ENSG00000204256ENST00000495733E9PIQ3
ENSG00000204256ENST00000496118J3QR72
ENSG00000204256ENST00000606059U3KPW0
ENSG00000204256ENST00000607833U3KQA6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
119831502002Genetic control of MHC class II expression.154
184063262008The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.138
232552182013BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.108
169405032006Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.88
109658462000RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.71
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
240491862013Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.63
165126642006Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines.61
250493792014Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.61
85958771996A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator.56

Citation

Dessen P

BRD2 (bromodomain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/836/brd2-(bromodomain-containing-2)