BRD2 (bromodomain containing 2)

2003-02-01  

Identity

HGNC
BRD2
LOCATION
6p21.32
LOCUSID
6046
ALIAS
BRD2-IT1,D6S113E,FSH,FSRG1,NAT,O27.1.1,RING3,RNF3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6046
MIM: 601540
HGNC: 1103
Ensembl: ENSG00000204256

Variants:

dbSNP: 6046
ClinVar: 6046
TCGA: ENSG00000204256
COSMIC: BRD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204256ENST00000374825P25440
ENSG00000204256ENST00000374825A0A024RCR5
ENSG00000204256ENST00000374831P25440
ENSG00000204256ENST00000374831A0A024RCR5
ENSG00000204256ENST00000395287P25440
ENSG00000204256ENST00000449025H0Y6K2
ENSG00000204256ENST00000449085P25440
ENSG00000204256ENST00000449085X5CF57
ENSG00000204256ENST00000456339H0Y799
ENSG00000204256ENST00000481259H0YDJ7
ENSG00000204256ENST00000482914E9PKQ9
ENSG00000204256ENST00000495733E9PIQ3
ENSG00000204256ENST00000496118J3QR72
ENSG00000204256ENST00000606059U3KPW0
ENSG00000204256ENST00000607833U3KQA6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370593382023The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.0
370593382023The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.0
332346762021BRD2 regulation of sigma-2 receptor upon cholesterol deprivation.13
343461162021PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance.8
332346762021BRD2 regulation of sigma-2 receptor upon cholesterol deprivation.13
343461162021PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance.8
317920582020Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.12
321512782020Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.10
324590532020BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma.15
344933642020Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.7
317920582020Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.12
321512782020Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.10
324590532020BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma.15
344933642020Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.7
307197122019No evidence for a BRD2 promoter hypermethylation in blood leukocytes of Europeans with juvenile myoclonic epilepsy.2

Citation

Dessen P

BRD2 (bromodomain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/836/css/gene-explorer/hgnc