BTG3 (BTG anti-proliferation factor 3)

2003-02-01  

Identity

HGNC
BTG3
LOCATION
21q21.1
LOCUSID
10950
ALIAS
ANA,ANA/BTG3,APRO4,TOB5,TOB55,TOFA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10950
MIM: 605674
HGNC: 1132
Ensembl: ENSG00000154640

Variants:

dbSNP: 10950
ClinVar: 10950
TCGA: ENSG00000154640
COSMIC: BTG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154640ENST00000339775Q14201
ENSG00000154640ENST00000348354Q14201
ENSG00000154640ENST00000348354Q6IAU3
ENSG00000154640ENST00000457956C9JLA2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192210002009BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer.74
176906882007The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1.40
220203312012Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis.16
291978762017MiR-106b-5p Promotes Proliferation and Inhibits Apoptosis by Regulating BTG3 in Non-Small Cell Lung Cancer.11
185900532008Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells.10
235332802013Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.10
252387032015Down-regulation of BTG3 promotes cell proliferation, migration and invasion and predicts survival in gastric cancer.10
238103942013Downregulation of BTG3 in non-small cell lung cancer.8
257013592015BTG3 upregulation induces cell apoptosis and suppresses invasion in esophageal adenocarcinoma.6
274688742016B-cell translocation gene 3 overexpression inhibits proliferation and invasion of colorectal cancer SW480 cells via Wnt/β-catenin signaling pathway.6

Citation

Dessen P

BTG3 (BTG anti-proliferation factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/849/btg3-(btg-anti-proliferation-factor-3)