C1QTNF6 (C1q and TNF related 6)

2003-06-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
CTFP6,CTRP6,ZACRP6
FUSION GENES

Other Information

Locus ID:

NCBI: 114904
MIM: 614910
HGNC: 14343
Ensembl: ENSG00000133466

Variants:

dbSNP: 114904
ClinVar: 114904
TCGA: ENSG00000133466
COSMIC: C1QTNF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133466ENST00000337843Q9BXI9
ENSG00000133466ENST00000337843A0A024R1J0
ENSG00000133466ENST00000397110Q9BXI9
ENSG00000133466ENST00000397110A0A024R1J0
ENSG00000133466ENST00000434784F8WC87

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
204105012010Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.102
202035242010Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.16
287266402017C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance.12
215085312011Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma.10
264044642015CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.8
259627012015C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation.5
300839832018C1q/TNF-related protein-6 is associated with insulin resistance and the development of diabetes in Chinese population.2
271551582016CTRP6 inhibits fibrogenesis in TGF-β1-stimulated human dermal fibroblasts.1
304310962019C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells.1

Citation

Dessen P

C1QTNF6 (C1q and TNF related 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/878/c1qtnf6-(c1q-and-tnf-related-6)