Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
AHUS5,ARMD9,ASP,C3a,C3b,CPAMD1,HEL-S-62p
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 718
MIM: 120700
HGNC: 1318
Ensembl: ENSG00000125730
Variants:
dbSNP: 718
ClinVar: 718
TCGA: ENSG00000125730
COSMIC: C3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162370415 | Metabolic Syndrome | Disease | ClinicalAnnotation | associated | PD | 26503818 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 26503818 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37795781 | 2024 | Defective C3d caused by C3 p.W1034R in inherited atypical hemolytic uremic syndrome. | 1 |
| 37926509 | 2024 | Complement C3 as a potential drug target in periodontitis: Evidence from the cis-Mendelian randomization approach. | 1 |
| 38251716 | 2024 | HylS', a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b. | 0 |
| 38255787 | 2024 | Serum Uric Acid Associates with Systemic Complement C3 Activation in Severe ANCA-Associated Renal Vasculitides. | 0 |
| 38310540 | 2024 | Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion. | 0 |
| 38411315 | 2024 | Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease. | 1 |
| 38795684 | 2024 | Complement decay-accelerating factor inhibits inflammation-induced myopia development. | 0 |
| 37795781 | 2024 | Defective C3d caused by C3 p.W1034R in inherited atypical hemolytic uremic syndrome. | 1 |
| 37926509 | 2024 | Complement C3 as a potential drug target in periodontitis: Evidence from the cis-Mendelian randomization approach. | 1 |
| 38251716 | 2024 | HylS', a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b. | 0 |
| 38255787 | 2024 | Serum Uric Acid Associates with Systemic Complement C3 Activation in Severe ANCA-Associated Renal Vasculitides. | 0 |
| 38310540 | 2024 | Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion. | 0 |
| 38411315 | 2024 | Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease. | 1 |
| 38795684 | 2024 | Complement decay-accelerating factor inhibits inflammation-induced myopia development. | 0 |
| 35017157 | 2023 | Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma. | 4 |
Citation
Dessen P
C3 (complement C3)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/886/c3-(complement-c3)
