LPCAT3 (lysophosphatidylcholine acyltransferase 3)

2003-12-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
C3F,LPCAT,LPLAT
FUSION GENES

Other Information

Locus ID:

NCBI: 10162
MIM: 611950
HGNC: 30244
Ensembl: ENSG00000111684

Variants:

dbSNP: 10162
ClinVar: 10162
TCGA: ENSG00000111684
COSMIC: LPCAT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111684ENST00000261407Q6P1A2
ENSG00000111684ENST00000535479F5H0M4
ENSG00000111684ENST00000536797F5GYT3
ENSG00000111684ENST00000538910F5H680
ENSG00000111684ENST00000540090F5H7K7
ENSG00000111684ENST00000543794B7Z3N5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

References

Pubmed IDYearTitleCitations
380734442024Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.1
385199812024Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.1
380734442024Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.1
385199812024Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.1
371663522023LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.11
371663522023LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.11
352868682022The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism.9
352868682022The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism.9
327808982020Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.13
327808982020Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.13
301607862019Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.8
301607862019Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.8
279136212017Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.18
286834452017Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.11
279136212017Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.18

Citation

Dessen P

LPCAT3 (lysophosphatidylcholine acyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/887/lpcat3-(lysophosphatidylcholine-acyltransferase-3)