Identity
HGNC
LOCATION
6q21
LOCUSID
ALIAS
ACT1,C6orf2,C6orf4,C6orf5,C6orf6,CANDF8,CIKS,PSORS13
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10758
MIM: 607043
HGNC: 1343
Ensembl: ENSG00000056972
Variants:
dbSNP: 10758
ClinVar: 10758
TCGA: ENSG00000056972
COSMIC: TRAF3IP2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| IL-17 signaling pathway | KEGG | ko04657 |
| IL-17 signaling pathway | KEGG | hsa04657 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444059 | Epidermal Necrolysis, Toxic | Disease | VariantAnnotation | associated | PD | ||
| PA445738 | Stevens-Johnson Syndrome | Disease | VariantAnnotation | associated | PD | ||
| PA447230 | HIV | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA450616 | nevirapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36544242 | 2023 | αCT1 peptide sensitizes glioma cells to temozolomide in a glioblastoma organoid platform. | 4 |
| 36978108 | 2023 | NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. | 3 |
| 36544242 | 2023 | αCT1 peptide sensitizes glioma cells to temozolomide in a glioblastoma organoid platform. | 4 |
| 36978108 | 2023 | NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. | 3 |
| 35441794 | 2022 | TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-β1/Smad pathway. | 2 |
| 35642993 | 2022 | A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients. | 3 |
| 35441794 | 2022 | TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-β1/Smad pathway. | 2 |
| 35642993 | 2022 | A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients. | 3 |
| 33359359 | 2021 | Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency. | 6 |
| 33825088 | 2021 | A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis. | 8 |
| 34140493 | 2021 | Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. | 12 |
| 33359359 | 2021 | Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency. | 6 |
| 33825088 | 2021 | A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis. | 8 |
| 34140493 | 2021 | Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. | 12 |
| 32350852 | 2020 | A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans. | 7 |
Citation
Dessen P
TRAF3IP2 (TRAF3 interacting protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/891/traf3ip2-(traf3-interacting-protein-2)
