CA6 (carbonic anhydrase 6)

2003-05-01  

Identity

HGNC
LOCATION
1p36.23
LOCUSID
ALIAS
CA-VI,GUSTIN
FUSION GENES

Other Information

Locus ID:

NCBI: 765
MIM: 114780
HGNC: 1380
Ensembl: ENSG00000131686

Variants:

dbSNP: 765
ClinVar: 765
TCGA: ENSG00000131686
COSMIC: CA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131686ENST00000377436P23280
ENSG00000131686ENST00000377442P23280
ENSG00000131686ENST00000377443P23280
ENSG00000131686ENST00000480186Q8N4G4
ENSG00000131686ENST00000549778F8W148

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217120492011Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype.35
206312032010Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans.33
206312032010Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans.33
240401922013The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance.22
245341762014Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6.21
254474752015The gustin (CA6) gene polymorphism, rs2274333 (A/G), is associated with fungiform papilla density, whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population.14
263775692016Gene-environment Interactions in the Etiology of Dental Caries.13
223660922012Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.10
197214662010Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years.9

Citation

Dessen P

CA6 (carbonic anhydrase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/897/ca6-(carbonic-anhydrase-6)