Identity
HGNC
LOCATION
18q11.2
LOCUSID
ALIAS
CABL1,CABLES,HsT2563,IK3-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 91768
MIM: 609194
HGNC: 25097
Ensembl: ENSG00000134508
Variants:
dbSNP: 91768
ClinVar: 91768
TCGA: ENSG00000134508
COSMIC: CABLES1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Factors involved in megakaryocyte development and platelet production | REACTOME | R-HSA-983231 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37555665 | 2023 | CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism. | 0 |
| 37555665 | 2023 | CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism. | 0 |
| 28118639 | 2017 | Cables1 Inhibits Proliferation and Induces Senescence by Angiotensin II via a p21-Dependent Pathway in Human Umbilical Vein Endothelial Cells. | 4 |
| 28533356 | 2017 | Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. | 29 |
| 28583208 | 2017 | miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit(+) cells to promote proliferation and inhibit apoptosis through a negative feedback loop. | 11 |
| 28118639 | 2017 | Cables1 Inhibits Proliferation and Induces Senescence by Angiotensin II via a p21-Dependent Pathway in Human Umbilical Vein Endothelial Cells. | 4 |
| 28533356 | 2017 | Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. | 29 |
| 28583208 | 2017 | miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit(+) cells to promote proliferation and inhibit apoptosis through a negative feedback loop. | 11 |
| 26695862 | 2016 | The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease. | 20 |
| 26695862 | 2016 | The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease. | 20 |
| 24975575 | 2015 | Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3. | 29 |
| 25361894 | 2015 | Cables1 complex couples survival signaling to the cell death machinery. | 29 |
| 24975575 | 2015 | Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3. | 29 |
| 25361894 | 2015 | Cables1 complex couples survival signaling to the cell death machinery. | 29 |
| 21890215 | 2011 | No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population. | 2 |
Citation
Dessen P
CABLES1 (Cdk5 and Abl enzyme substrate 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/900/cables1-(cdk5-and-abl-enzyme-substrate-1)
