CAMK4 (calcium/calmodulin dependent protein kinase IV)

2003-11-01 Affiliation

Identity

HGNC

CAMK4

LOCATION

5q22.1

LOCUSID

814

ALIAS

CaMK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 814
MIM: 114080
HGNC: 1464
Ensembl: ENSG00000152495

Variants:

dbSNP: 814
ClinVar: 814
TCGA: ENSG00000152495
COSMIC: CAMK4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152495	ENST00000282356	Q16566
ENSG00000152495	ENST00000504544	D6RCD6
ENSG00000152495	ENST00000508074	D6RE65
ENSG00000152495	ENST00000512453	Q16566
ENSG00000152495	ENST00000514007	D6REY7
ENSG00000152495	ENST00000515231	D6RCD6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Long-term potentiation	KEGG	ko04720
Calcium signaling pathway	KEGG	hsa04020
Long-term potentiation	KEGG	hsa04720
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Cholinergic synapse	KEGG	hsa04725
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of CaMKK	REACTOME	R-HSA-442717
Activation of CaMK IV	REACTOME	R-HSA-442745
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
CaMK IV-mediated phosphorylation of CREB	REACTOME	R-HSA-111932
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Longevity regulating pathway	KEGG	hsa04211
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15841182	2005	Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.	82
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19506079	2009	Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.	61
18606955	2008	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.	55
24667640	2014	CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.	53
18829949	2008	Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging.	41
20378615	2010	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	40
21612516	2011	Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.	38
17909078	2008	Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.	33
27298345	2016	Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.	29

Citation

Dessen P

CAMK4 (calcium/calmodulin dependent protein kinase IV)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/906/camk4-(calcium-calmodulin-dependent-protein-kinase-iv)