CASP10 (caspase 10)

2003-02-01  

Identity

HGNC
CASP10
LOCATION
2q33.1
LOCUSID
843
ALIAS
ALPS2,FLICE-2,FLICE2,MCH4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 843
MIM: 601762
HGNC: 1500
Ensembl: ENSG00000003400

Variants:

dbSNP: 843
ClinVar: 843
TCGA: ENSG00000003400
COSMIC: CASP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003400ENST00000272879Q92851
ENSG00000003400ENST00000286186Q92851
ENSG00000003400ENST00000286186A0A0S2Z3Z5
ENSG00000003400ENST00000313728Q92851
ENSG00000003400ENST00000346817Q92851
ENSG00000003400ENST00000346817A0A0S2Z3G5
ENSG00000003400ENST00000360132Q92851
ENSG00000003400ENST00000374650Q92851
ENSG00000003400ENST00000438843B4E3T5
ENSG00000003400ENST00000448480Q92851

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Hepatitis BKEGGhsa05161
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
FasL/ CD95L signalingREACTOMER-HSA-75157
TRAIL signalingREACTOMER-HSA-75158
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387043742024Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome.0
387043742024Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome.0
363230682022Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death.2
363230682022Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death.2
330490892021Long noncoding RNA PVT1 facilitates high glucose-induced cardiomyocyte death through the miR-23a-3p/CASP10 axis.5
343297982021Variants in CASP10, a diagnostic challenge: Single center experience and review of the literature.4
344639272021Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis.7
330490892021Long noncoding RNA PVT1 facilitates high glucose-induced cardiomyocyte death through the miR-23a-3p/CASP10 axis.5
343297982021Variants in CASP10, a diagnostic challenge: Single center experience and review of the literature.4
344639272021Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis.7
315341412019Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis.20
315341412019Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis.20
293227882018MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression.17
293227882018MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression.17
277992922017SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis.14

Citation

Dessen P

CASP10 (caspase 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/916/casp10-(caspase-10)