CASP10 (caspase 10)

2003-02-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
ALPS2,FLICE-2,FLICE2,MCH4
FUSION GENES

Other Information

Locus ID:

NCBI: 843
MIM: 601762
HGNC: 1500
Ensembl: ENSG00000003400

Variants:

dbSNP: 843
ClinVar: 843
TCGA: ENSG00000003400
COSMIC: CASP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003400ENST00000272879Q92851
ENSG00000003400ENST00000286186Q92851
ENSG00000003400ENST00000286186A0A0S2Z3Z5
ENSG00000003400ENST00000313728Q92851
ENSG00000003400ENST00000346817Q92851
ENSG00000003400ENST00000346817A0A0S2Z3G5
ENSG00000003400ENST00000360132Q92851
ENSG00000003400ENST00000374650Q92851
ENSG00000003400ENST00000438843B4E3T5
ENSG00000003400ENST00000448480Q92851

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Hepatitis BKEGGhsa05161
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
FasL/ CD95L signalingREACTOMER-HSA-75157
TRAIL signalingREACTOMER-HSA-75158
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235419522013Control of autophagic cell death by caspase-10 in multiple myeloma.83
121981542002Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.79
174501412007A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.74
226832652012Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.70
154521172004Taxol induces caspase-10-dependent apoptosis.53
199022552010Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.53
161868082006Unique and overlapping substrate specificities of caspase-8 and caspase-10.38
198616802010The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells.36
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
194235372009Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.28

Citation

Dessen P

CASP10 (caspase 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/916/casp10-(caspase-10)