CASP3 (caspase 3)

2003-08-01  

Identity

HGNC
LOCATION
4q35.1
LOCUSID
ALIAS
CPP32,CPP32B,SCA-1

Other Information

Locus ID:

NCBI: 836
MIM: 600636
HGNC: 1504
Ensembl: ENSG00000164305

Variants:

dbSNP: 836
ClinVar: 836
TCGA: ENSG00000164305
COSMIC: CASP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164305ENST00000308394P42574
ENSG00000164305ENST00000393585A8MVM1
ENSG00000164305ENST00000393588A8MVM1
ENSG00000164305ENST00000447121C9JXR7
ENSG00000164305ENST00000517513A8MVM1
ENSG00000164305ENST00000523916P42574

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Huntington's diseaseKEGGko05016
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Colorectal cancerKEGGko05210
MAPK signaling pathwayKEGGhsa04010
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Huntington's diseaseKEGGhsa05016
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Viral myocarditisKEGGhsa05416
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Serotonergic synapseKEGGhsa04726
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Apoptotic machineryKEGGhsa_M00685
Apoptotic machineryKEGGM00685
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NADE modulates death signallingREACTOMER-HSA-205025
Signaling by HippoREACTOMER-HSA-2028269
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Apoptotic factor-mediated responseREACTOMER-HSA-111471
Cytochrome c-mediated apoptotic responseREACTOMER-HSA-111461
Activation of caspases through apoptosome-mediated cleavageREACTOMER-HSA-111459
SMAC-mediated apoptotic responseREACTOMER-HSA-111469
SMAC binds to IAPsREACTOMER-HSA-111463
SMAC-mediated dissociation of IAP:caspase complexesREACTOMER-HSA-111464
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Stimulation of the cell death response by PAK-2p34REACTOMER-HSA-211736
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA26094CASP9GenePathwayassociated
PA448871celecoxibChemicalPathwayassociated22336956
PA95CCNB1GenePathwayassociated

References

Pubmed IDYearTitleCitations
383221642024Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients.0
383755952024A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells.0
386150432024MiR-98-5p plays suppressive effects on IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting CASP3.0
386409192024A Non-Apoptotic Pattern of Caspase-9/Caspase-3 Activation During Differentiation of Human Embryonic Stem Cells into Cardiomyocytes.0
387034752024Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis.1
383221642024Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients.0
383755952024A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells.0
386150432024MiR-98-5p plays suppressive effects on IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting CASP3.0
386409192024A Non-Apoptotic Pattern of Caspase-9/Caspase-3 Activation During Differentiation of Human Embryonic Stem Cells into Cardiomyocytes.0
387034752024Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis.1
353546452023Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.4
366376262023Evaluation of the Expression of miRNAs, LncRNAs, and their Target Gene, Caspase 3 in Glioblastoma Multiform: A Case-Control Study.0
366752072023Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour.4
369018802023Traumatic Brain Injury Induces Microglial and Caspase3 Activation in the Retina.3
370740042023Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series.0

Citation

Dessen P

CASP3 (caspase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/920/casp3-(caspase-3)