CASP4 (caspase 4)

2003-08-01  

Identity

HGNC
CASP4
LOCATION
11q22.3
LOCUSID
837
ALIAS
ICE(rel)II,ICEREL-II,ICH-2,Mih1,Mih1/TX,TX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 837
MIM: 602664
HGNC: 1505
Ensembl: ENSG00000196954

Variants:

dbSNP: 837
ClinVar: 837
TCGA: ENSG00000196954
COSMIC: CASP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196954ENST00000393150P49662
ENSG00000196954ENST00000417440E9PMT1
ENSG00000196954ENST00000444739P49662
ENSG00000196954ENST00000533252H0YD34

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
251190342014Inflammatory caspases are innate immune receptors for intracellular LPS.412
151237402004Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.242
251217522014Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.108
265083692015Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.66
259643522015Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.64
261740852015Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.64
222466302012Caspase-4 is required for activation of inflammasomes.58
261739882015NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.53
236843082013The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.41
248797912014A critical role for human caspase-4 in endotoxin sensitivity.40

Citation

Dessen P

CASP4 (caspase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/921/casp4-(caspase-4)