Identity
HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
ICE(rel)II,ICEREL-II,ICH-2,Mih1,Mih1/TX,TX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 837
MIM: 602664
HGNC: 1505
Ensembl: ENSG00000196954
Variants:
dbSNP: 837
ClinVar: 837
TCGA: ENSG00000196954
COSMIC: CASP4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196954 | ENST00000393150 | P49662 |
| ENSG00000196954 | ENST00000417440 | E9PMT1 |
| ENSG00000196954 | ENST00000444739 | P49662 |
| ENSG00000196954 | ENST00000533252 | H0YD34 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38459541 | 2024 | Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma. | 2 |
| 38459541 | 2024 | Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma. | 2 |
| 36763010 | 2023 | CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation. | 3 |
| 37296437 | 2023 | Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis. | 1 |
| 37589460 | 2023 | Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. | 5 |
| 37993712 | 2023 | Structural insights into cytokine cleavage by inflammatory caspase-4. | 7 |
| 38139378 | 2023 | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | 1 |
| 36763010 | 2023 | CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation. | 3 |
| 37296437 | 2023 | Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis. | 1 |
| 37589460 | 2023 | Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. | 5 |
| 37993712 | 2023 | Structural insights into cytokine cleavage by inflammatory caspase-4. | 7 |
| 38139378 | 2023 | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | 1 |
| 34916628 | 2022 | Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. | 12 |
| 35132157 | 2022 | The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli. | 6 |
| 35303042 | 2022 | The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion. | 7 |
Citation
Dessen P
CASP4 (caspase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/921/casp4-(caspase-4)
