CASP6 (caspase 6)

2003-08-01  

Identity

HGNC
CASP6
LOCATION
4q25
LOCUSID
839
ALIAS
MCH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 839
MIM: 601532
HGNC: 1507
Ensembl: ENSG00000138794

Variants:

dbSNP: 839
ClinVar: 839
TCGA: ENSG00000138794
COSMIC: CASP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138794ENST00000265164P55212
ENSG00000138794ENST00000352981P55212
ENSG00000138794ENST00000503684D6RHU3
ENSG00000138794ENST00000505486D6RBM3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Breakdown of the nuclear laminaREACTOMER-HSA-352238
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153562022004Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.72
173921602007Activation of caspase-6 in aging and mild cognitive impairment.65
120893222002Apoptotic threshold is lowered by p53 transactivation of caspase-6.41
152804692004Caspases mediate processing of the capsid precursor and cell release of human astroviruses.37
208903112010Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.36
211117462011Substrate-induced conformational changes occur in all cleaved forms of caspase-6.32
228912502012Zinc-mediated allosteric inhibition of caspase-6.30
199154872009Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.29
196946152009The crystal structure of caspase-6, a selective effector of axonal degeneration.28
161237792006Caspase-1 activation of caspase-6 in human apoptotic neurons.26

Citation

Dessen P

CASP6 (caspase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/923/casp6-(caspase-6)