CBLL1 (Cbl proto-oncogene like 1)

2003-12-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
HAKAI,RNF188
FUSION GENES

Other Information

Locus ID:

NCBI: 79872
MIM: 606872
HGNC: 21225
Ensembl: ENSG00000105879

Variants:

dbSNP: 79872
ClinVar: 79872
TCGA: ENSG00000105879
COSMIC: CBLL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105879ENST00000222597Q75N03
ENSG00000105879ENST00000415884C9K074
ENSG00000105879ENST00000420796C9J2P9
ENSG00000105879ENST00000432748F8WEM5
ENSG00000105879ENST00000440859Q75N03

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Listeria monocytogenes entry into host cellsREACTOMER-HSA-8876384
InlA-mediated entry of Listeria monocytogenes into host cellsREACTOMER-HSA-8876493

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383391952024Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours.0
383391952024Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours.0
380620632023CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.0
380620632023CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.0
362664282022Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.4
362664282022Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.4
311242982019CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion.17
316465692019Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells.17
311242982019CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion.17
316465692019Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells.17
294726342018Hakai overexpression effectively induces tumour progression and metastasis in vivo.18
297861072018E3 ubiquitin ligase Hakai regulates cell growth and invasion, and increases the chemosensitivity to cisplatin in non‑small‑cell lung cancer cells.11
294726342018Hakai overexpression effectively induces tumour progression and metastasis in vivo.18
297861072018E3 ubiquitin ligase Hakai regulates cell growth and invasion, and increases the chemosensitivity to cisplatin in non‑small‑cell lung cancer cells.11
280694392017Hakai, an E3-ligase for E-cadherin, stabilizes δ-catenin through Src kinase.6

Citation

Dessen P

CBLL1 (Cbl proto-oncogene like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/935/cbll1-(cbl-proto-oncogene-like-1)