CCL14 (C-C motif chemokine ligand 14)

2003-05-01  

Identity

HGNC
CCL14
LOCATION
17q12
LOCUSID
6358
ALIAS
CC-1,CC-3,CKB1,HCC-1,HCC-1(1-74),HCC-1/HCC-3,HCC-3,MCIF,NCC-2,NCC2,SCYA14,SCYL2,SY14

Other Information

Locus ID:

NCBI: 6358
MIM: 601392
HGNC: 10612
Ensembl: ENSG00000276409

Variants:

dbSNP: 6358
ClinVar: 6358
TCGA: ENSG00000276409
COSMIC: CCL14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000276409ENST00000614009A0A087X089
ENSG00000276409ENST00000618404Q16627
ENSG00000276409ENST00000620991A0A0B4J2G5
ENSG00000276409ENST00000622526Q16627

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
219376842011Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.49
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
198125442010A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.19
261559422015Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.18
183676762008CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation.17
205032872010Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.17
196329872009Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence.16
176918232007Structural and functional characterization of CC chemokine CCL14.13

Citation

Dessen P

CCL14 (C-C motif chemokine ligand 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/940/ccl14-(c-c-motif-chemokine-ligand-14)