CCL4 (C-C motif chemokine ligand 4)

2003-08-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
ACT2,AT744.1,G-26,HC21,LAG-1,LAG1,MIP-1-beta,MIP1B,MIP1B1,SCYA2,SCYA4
FUSION GENES

Other Information

Locus ID:

NCBI: 6351
MIM: 182284
HGNC: 10630
Ensembl: ENSG00000275302

Variants:

dbSNP: 6351
ClinVar: 6351
TCGA: ENSG00000275302
COSMIC: CCL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275302ENST00000615863P13236
ENSG00000275302ENST00000621626Q7M4M2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124014802002Macrophage inflammatory protein-1.171
231525592012Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.118
190747302009High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation.110
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
209598072010Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.49
198468702009Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment.47
122003852002Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma.44
120368552002Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5.42
221563482012IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.33
147619322004Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4.31

Citation

Dessen P

CCL4 (C-C motif chemokine ligand 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/945/ccl4-(c-c-motif-chemokine-ligand-4)