CCNA2 (cyclin A2)

Identity

HGNC

CCNA2

LOCATION

4q27

LOCUSID

890

ALIAS

CCN1,CCNA

Other Information

Locus ID:

NCBI: 890
MIM: 123835
HGNC: 1578
Ensembl: ENSG00000145386

Variants:

dbSNP: 890
ClinVar: 890
TCGA: ENSG00000145386
COSMIC: CCNA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000145386	ENST00000274026	P20248
ENSG00000145386	ENST00000618014	P20248

Expression (GTEx)

0

50

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	REACTOME	R-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACTOME	R-HSA-174184
Cell cycle	KEGG	ko04110
Cell cycle	KEGG	hsa04110
Cell Cycle	REACTOME	R-HSA-1640170

Previous1 2 3 4 5 6 7Next

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA451581	tamoxifen	Chemical	Literature, MultilinkAnnotation	associated			24622579

References

Pubmed ID	Year	Title	Citations
34366326	2022	E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity.	9
35401923	2022	CCNA2 as an Immunological Biomarker Encompassing Tumor Microenvironment and Therapeutic Response in Multiple Cancer Types.	17
35835355	2022	Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.	0
36655391	2023	Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.	0
36655391	2023	Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.	0
37276868	2023	Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis.	1
37276868	2023	Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis.	1
38363129	2024	Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.	2
38363129	2024	Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.	2
38640322	2024	CDK1 and CCNA2 play important roles in oral squamous cell carcinoma.	0

Previous1 2Next

Citation

Dessen P

CCNA2 (cyclin A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/950/ccna2-(cyclin-a2)