CCNG2 (cyclin G2)

Identity

HGNC

CCNG2

LOCATION

4q21.1

LOCUSID

901

ALIAS

-

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 901
MIM: 603203
HGNC: 1593
Ensembl: ENSG00000138764

Variants:

dbSNP: 901
ClinVar: 901
TCGA: ENSG00000138764
COSMIC: CCNG2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138764	ENST00000316355	Q16589
ENSG00000138764	ENST00000316355	A0A024RDC7
ENSG00000138764	ENST00000395640	Q16589
ENSG00000138764	ENST00000395640	A0A024RDC7
ENSG00000138764	ENST00000502280	Q16589
ENSG00000138764	ENST00000502280	A0A024RDC7
ENSG00000138764	ENST00000509972	Q16589
ENSG00000138764	ENST00000512918	D6RHI3

Expression (GTEx)

0

10

20

30

40

50

60

70

80

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
p53 signaling pathway	KEGG	hsa04115
FoxO signaling pathway	KEGG	hsa04068

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11956189	2002	Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.	72
16608856	2006	Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter.	59
25117811	2014	MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.	52
17123511	2006	Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest.	32
21532621	2011	Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells.	29
25309979	2015	MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma.	23
22589537	2012	Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.	21
18784254	2008	Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7.	20
26573378	2016	MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.	20
18025271	2007	Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.	18

Citation

Dessen P

CCNG2 (cyclin G2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/960/ccng2-(cyclin-g2)