Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8812
MIM: 603544
HGNC: 1596
Ensembl: ENSG00000090061
Variants:
dbSNP: 8812
ClinVar: 8812
TCGA: ENSG00000090061
COSMIC: CCNK
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA445113 | Neutropenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37597256 | 2023 | CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome. | 0 |
| 37597256 | 2023 | CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome. | 0 |
| 36129942 | 2022 | CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer. | 6 |
| 36129942 | 2022 | CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer. | 6 |
| 34289372 | 2021 | Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. | 28 |
| 34380030 | 2021 | HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity. | 9 |
| 34289372 | 2021 | Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. | 28 |
| 34380030 | 2021 | HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity. | 9 |
| 33042275 | 2020 | Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer. | 9 |
| 33042275 | 2020 | Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer. | 9 |
| 29474905 | 2018 | A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. | 54 |
| 29760377 | 2018 | Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. | 23 |
| 29760377 | 2018 | Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. | 23 |
| 30122539 | 2018 | De Novo Mutations of CCNK Cause a Syndromic Neurodevelopmental Disorder with Distinctive Facial Dysmorphism. | 9 |
| 29474905 | 2018 | A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. | 54 |
Citation
Dessen P
CCNK (cyclin K)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/962/ccnk-(cyclin-k)
