CD63 (CD63 molecule)

2003-06-01  

Identity

HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
LAMP-3,ME491,MLA1,OMA81H,TSPAN30
FUSION GENES

Other Information

Locus ID:

NCBI: 967
MIM: 155740
HGNC: 1692
Ensembl: ENSG00000135404

Variants:

dbSNP: 967
ClinVar: 967
TCGA: ENSG00000135404
COSMIC: CD63

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135404ENST00000257857P08962
ENSG00000135404ENST00000257857A0A024RB05
ENSG00000135404ENST00000420846P08962
ENSG00000135404ENST00000420846A0A024RB05
ENSG00000135404ENST00000546457F8VNT9
ENSG00000135404ENST00000546939P08962
ENSG00000135404ENST00000548160F8VV56
ENSG00000135404ENST00000548898F8VV56
ENSG00000135404ENST00000549117P08962
ENSG00000135404ENST00000549117A0A024RB05
ENSG00000135404ENST00000550050F8VX62
ENSG00000135404ENST00000550776P08962
ENSG00000135404ENST00000551173F8W022
ENSG00000135404ENST00000552067F8VV56
ENSG00000135404ENST00000552164F8VWK8
ENSG00000135404ENST00000552692P08962
ENSG00000135404ENST00000552692A0A024RB05
ENSG00000135404ENST00000552754P08962

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193813312009High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients.271
175222072007Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains.101
169175032006Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.99
164105522006Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis.93
215279132011LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation.78
119072832002Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes.71
169085302006Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63.52
194580022009Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells.49
279745662017CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling.49
206330312010Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes.44

Citation

Dessen P

CD63 (CD63 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/986/cd63-(cd63-molecule)