t(7;11)(p15;p15) NUP98/HOXA9

1999-01-01   Jean-Loup Huret , Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

AML mostly; occasionally: CML-like cases without t(9;22), or CMLin blast crisis (with t(9;22))

Phenotype stem cell origin

M2 or M4 AML mainly; involving maturingleukemic cells in AML cases, might affect trilineage progenitors inCML-like cases

Epidemiology

most cases have been found in Japan; balanced sex ratio

Cytology

auer rods; low alkaline phosphatase scores; CML likeblood features

Prognosis

CR in most cases; but patients tend to relapse; mean survival: 15mths

Genes Involved and Proteins

Gene name
HOXA9 (homeobox A9)
Location
7p15.2
Protein description
encodes a class I homeodomain protein potentiallycontains repeated motifs and a RNA binding motif;
Gene name
NUP98 (nucleoporin 98 kDa)
Location
11p15.4
Dna rna description
alternate splicings
Protein description
nucleoporin: role in nucleo-cytoplasmic transport

Result of the Chromosomal Anomaly

Description

5 NUP98 - 3 HOXA9fuses the N-term GLFG repeat domains of NUP98 to the HOXA9 3homeobox

Oncogenesis

may promote leukaemogenesis through inhibition ofHOXA9-mediated terminaldifferentiation and/or aberrant nucleocytoplasmic transport

Bibliography

No bibliography items were found for this article.

Summary

Fusion gene

NUP98/HOXA9 NUP98 (11p15.4) HOXA9 (7p15.2) M t(7;11)(p15;p15)|NUP98/HOXA9 NUP98 (11p15.4) HOXA9 (7p15.2) TIC
Atlas Image
t(7;11)(p15;p15) G-banding - Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services

Citation

Jean-Loup Huret ; Jean-Loup Huret

t(7;11)(p15;p15) NUP98/HOXA9

Atlas Genet Cytogenet Oncol Haematol. 1999-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1016/t(7;11)(p15;p15)-nup98-hoxa9

External Links