HOXA9 (homeobox A9)

1998-01-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
HOXA9
LOCATION
7p15.2
LOCUSID
3205
ALIAS
ABD-B,HOX1,HOX1.7,HOX1G
FUSION GENES
Show Gene Fusions

Proteins

Description

129 amino acids; DNA binding domain (homeobox) in C-term

Localisation

nuclear

Function

sequence specific transcription factor; role during embryonic development (patterning); HOX genes are also expressed in adult tissues, including blood cells; probable role in blood cell differenciation

Homology

with class 1 homeodomain proteins

Implicated in

Entity name
t(7;11)(p15;p15)/AML --> NUP98- HOXA9
Disease
M2-M4 AML mostly; occasionally: CML-like cases
Prognosis
mean survival: 15 mths
Cytogenetics
sole anomaly most often
Hybrid gene
5 NUP98 - 3 HOXA9
Fusion protein
fuses the GLFG repeat domains of NUP98 to the HOXA9 homeobox

Breakpoints

Atlas Image

Article Bibliography

Pubmed IDLast YearTitleAuthors
85637541996The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.Borrow J et al
90587121997Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.Lawrence HJ et al
85637531996Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.Nakamura T et al

Other Information

Locus ID:

NCBI: 3205
MIM: 142956
HGNC: 5109
Ensembl: ENSG00000078399

Variants:

dbSNP: 3205
ClinVar: 3205
TCGA: ENSG00000078399
COSMIC: HOXA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078399ENST00000343483P31269
ENSG00000078399ENST00000396345A8MVF3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382169722024RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.0
389046762024Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis.0
382169722024RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.0
389046762024Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis.0
347434042023Molecular regulators of HOXA9 in acute myeloid leukemia.14
365771372023HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.5
347434042023Molecular regulators of HOXA9 in acute myeloid leukemia.14
365771372023HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.5
348505512022ALKBH5-mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9.19
349134722022Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis.3
353725882022Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer.7
357432432022HOXA9 Overexpression Contributes to Stem Cell Overpopulation That Drives Development and Growth of Colorectal Cancer.5
358309662022Downregulation of hsa-miR-548d-3p and overexpression of HOXA9 in diffuse large B-cell lymphoma patients and the risk of R-CHOP chemotherapy resistance and disease progression.0
360654122022circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis.2
361924252022HOXA9 has the hallmarks of a biological switch with implications in blood cancers.6

Citation

Jean-Loup Huret

HOXA9 (homeobox A9)

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/gene/61/hoxa9-(homeobox-a9)