+9 or trisomy 9
2006-09-01 Ulrike Bacher , Claudia Haferlach Affiliation1.Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany
Clinics and Pathology
Disease
B-lineage acute lymphoblastic leukemia
Epidemiology
Rare in Philadelphia-positive and in Philadelphia-negative B-lineage.
Cytogenetics
Additional anomalies: Philadelphia-negative ALL: Occurrence in hyperdiploid karyotypes (equal or more than 47 chromosomes) mostly in combination with other numerical gains. Philadelphia-positive ALL: Rare additional change.
Genes
Not known.
Prognosis
Philadelphia-negative ALL with high hyperdiploid karyotype (equal or more than 51 chromosomes) shows a good prognosis, gain of chromosome 9 is not typical and prognostic impact of trisomy 9 in this setting unknown. In Philadelphia-positive ALL additional chromosomal anomalies probably enhance the inferior prognosis.
Disease
T-lineage acute lymphoblastic leukemia.
Epidemiology
Rare, up to 4% in childhood T-ALL.
Cytogenetics
Additional anomalies: Occurs as sole or as combined anomaly.
Genes
Not known.
Prognosis
So far a prognostic impact could not be defined, which also might be due to the low analyzed case numbers.
Cytogenetics
+9 (chromosome painting, WCP#9 (red))
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15692838 | 2005 | Conventional cytogenetics of myeloproliferative diseases other than CML contribute valid information. | Bacher U et al |
| 11503956 | 2001 | Chromosome and molecular abnormalities in myelodysplastic syndromes. | Fenaux P et al |
| 3708552 | 1986 | Numerical chromosome aberrations in human neoplasia. | Heim S et al |
| 2013980 | 1991 | Karyotypic patterns in chronic myeloproliferative disorders: report on 74 cases and review of the literature. | Mertens F et al |
| 12406101 | 2002 | Exploring polycythaemia vera with fluorescence in situ hybridization: additional cryptic 9p is the most frequent abnormality detected. | Najfeld V et al |
| 8982045 | 1996 | Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia. | Rieder H et al |
| 11001909 | 2000 | New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases. | Schneider NR et al |
Summary
Note
Occurs in a large spectrum of myeloid and lymphatic malignancies - chronic myeloproliferative disorders (CMPD), acute myeloid leukemias (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage. Strong association to the CMPD and especially to polycythemia vera (PV).
+9 (G-banding)
Citation
Ulrike Bacher ; Claudia Haferlach
+9 or trisomy 9
Atlas Genet Cytogenet Oncol Haematol. 2006-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1020/%2B9-or-trisomy-9
