+22 or trisomy 22 (solely?)

2000-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


acute myeloid leukemia (AML)

Phenotype stem cell origin

M4eo AML most often in cases associated with inv(16); M4 also, but only in 2/3 of cases ,when +22 is apparently without inv(16); and eosinophilia may be missing in the latter case


young age, both in cases with or without inv(16)


inv(16) may be at increased CNS relapse when +22 is also present


a fair prognosis is associated with +22 accompanying inv(16), and with +22 solely, comparable to the prognosis associated with inv(16)


Cytogenetics morphological

+22 is a frequent anomaly additional to inv(16), but was not found associated with other anomalies recurrently found in de novo AML; +22 may also occur apparently in the absence of inv(16), but cryptic rearrangements of MYH11 (16p13) and CBFB (16q22) have been found in a number of cases; for some authors, +22 indicates the obligate existence of an inv(16); for others +22 solely is a true entity

Cytogenetics molecular

is appropriate to exclude or discover the presence of a hidden inv(16), inasmuch as inv(16) is associated with a relatively good prognosis

Additional anomalies

anomalies associated with +22 are del(7q) and/or +8, found in15% of cases each; this percentage is similar in cases with or without inv(16)


Pubmed IDLast YearTitleAuthors
27907671989Is trisomy 22 in acute myeloid leukemia a primary abnormality or only a secondary change associated with inversion 16?Grois N et al
82079901994Secondary chromosomal abnormalities in acute leukemias.Johansson B et al
96095311998A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. MRC Adult Leukaemia Working Party. Medical Research Council.Langabeer SE et al
34653761986Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.Larson RA et al
31637441988Central nervous system involvement in acute nonlymphocytic leukemia with inv(16)(p13q22).Ohyashiki K et al
100879461999Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16.Wong KF et al



+22 is often associated with inv(16)(p13q22) or its equivalents; the existence of trisomy 22 solely is debated


Jean-Loup Huret

+22 or trisomy 22 (solely?)

Atlas Genet Cytogenet Oncol Haematol. 2000-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1042/+22-or-trisomy-22-(solely-)