t(1;19)(q23;p13) TCF3/PBX1
2012-07-01 Cristina N Alonso Affiliation1.Hematology-Oncology Department, Hospital Nacional de Pediatria Garrahan, Combate de los Pozos 1881- Zip Code : 1245. Buenos Aires, Republica Argentina
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers France
Clinics and Pathology
Disease
Phenotype stem cell origin
Most cases: pre B (cIg+) ALL; may be cIg- or sIg+.
CD45dim, CD19pos, CD34neg, CD22pos/dim, CD20dim/pos, CD24pos, TdTpos, CD10neg/dim, cIgMpos, CD9pos, CD15neg, CD65neg, CD66cneg, CD13neg, CD33neg.
CD45dim, CD19pos, CD34neg, CD22pos/dim, CD20dim/pos, CD24pos, TdTpos, CD10neg/dim, cIgMpos, CD9pos, CD15neg, CD65neg, CD66cneg, CD13neg, CD33neg.
Epidemiology
5% of ALL, or 20% of pre B ALL; found in children and young adults (1-60 yrs, median: 10 yrs --> one of the most frequent ALL in childhood (4-6%)); 3 male/4 female patients.
Clinics
Moderate organomegaly; frequent CNS involvement; blood data: high WBC (median 20 x 109/L); high LDH.
Treatment
Treatment should be adapted to biological features at the moment of diagnosis and also to early chemotherapy response and risk group stratification should not be based on TCF3-PBX1 detection.
Prognosis
Although this chromosomal abnormality usually discloses adverse prognostic features (WBC, SNC), it is associated with good prognosis with modern intensive protocols. Median 5 yr-event free survival probability in childhood ALL: 85(6)%; no age or blood data prognostic significance; there are no differences between the prognosis of balanced or unbalanced forms. Prognosis in adults is not different between TCF3-PBX1 positive and negative cases (pEFS: 40 vs. 44%).
Cytogenetics
Cytogenetics morphological
Breakpoint is in 19p13.3; two different forms (see diagrams above): - the balanced t(1;19), one fourth of cases, with a der(1) and a der(19); - the unbalanced form, found in 3/4 cases, with 2 normal chromosomes 1, a der(19), and 1 normal chromosome 19: --> partial trisomy for 1q23-1qter and monosomy for 19p13.3-pter; the 2 forms can be in mosaic; note: 19p13 and 19q13 may be confused (e.g. literature reports). A subset of ALL usually hyperdyploid B-ALL has an identical t(1;19) that lack the expected phenotype probably do not represent TCF3-PBX1 B-ALL.
Additional anomalies
t(17;19)(q22;p13) is not stricto sensu a variant, but, so far, an equivalent, with HLF (hepatic leukemia factor), on 17q22, involved in the translocation. Additional anomalies are found in half of the cases, mostly partial dup (1q), +6, del(6q), +8, i(9q), +17, i(17q), +21.
Genes Involved and Proteins
Note
The following are (most often) involved, except in some cases lacking the cIg expression:
Gene name
PBX1 (pre-B-cell leukemia homeobox 1)
Location
1q23.3
Note
Previously known as "pre-B-cell leukemia transcription factor 1".
Dna rna description
Alternate splicing (variants 1, 2 and 3) (Acc Numbers: NM_001204963.1, NM_001204961.1 and NM_002585.3).
c-PBX1 at 1q23 in normal cells: PAC 1146N1 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Protein description
Nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Contains a homeodomain to bind to DNA.
Gene name
TCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Location
19p13.3
Note
Other names: bHLHb21, E2A, "E2A immunoglobulin enhancer-binding factor E12/E47", E47, "immunoglobulin transcription factor 1", ITF1, "kappa-E2-binding factor", MGC129647, MGC129648, "transcription factor E2-alpha", VDIR, "VDR interacting repressor".
Dna rna description
Alternate splicing 2 isoforms --> E12 and E47. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Protein description
Contains transcriptional activation domains and a basic helix-loop-helix DNA binding site; binds specifically to an immunoglobulin enhancer; nuclear localization; transcription factor.
Result of the Chromosomal Anomaly
Description
5 TCF3 exons fused to 3 PBX1; breakpoints are clustered on both genes; the reciprocal 5 PBX1 - 3 E2A is not transcribed.
Transcript
Most cases present fusion of exons 1-16 in TCF3 to exons 4-9 in PBX1. Alternative breakpoint in intron 4 of PBX1, not detectable by standardized RT-PCR primers, has been reported.
Description
550 amino acids; 85 kDa; N-term transcriptional activation domains from TCF3 fused to the Hox cooperative motif and homeodomain of C-term PBX1; potent transcriptional activator.
Expression localisation
Nuclear localisation.
Oncogenesis
Pleiotropic transforming activity. The resulting fusion protein (TCF3-PBX1), in which the DNA binding domain of E2A is replaced by the DNA binding domain of TCF3, transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members the PBX protein family.
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 24811161 | 2014 | Targeting the B-cell receptor signaling pathway in B lymphoid malignancies. | 90 |
| 39377397 | 2024 | Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4. | 89 |
| 25273558 | 2014 | Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia. | 86 |
| 26214592 | 2015 | Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. | 85 |
| 31902036 | 2020 | Insights into the prenatal origin of childhood acute lymphoblastic leukemia. | 82 |
| 36011285 | 2022 | Commonly Assessed Markers in Childhood BCP-ALL Diagnostic Panels and Their Association with Genetic Aberrations and Outcome Prediction. | 74 |
| 37019972 | 2023 | Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication. | 71 |
| 33895809 | 2021 | Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL. | 70 |
| 32029838 | 2020 | Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia. | 66 |
| 35719952 | 2022 | Underexpression of LINC00173 in TCF3/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia. | 65 |
| 36670235 | 2023 | Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia. | 60 |
| 33890726 | 2021 | CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways. | 59 |
| 39901941 | 2025 | Dynamic evolution of TCF3-PBX1 leukemias at the single-cell level under chemotherapy pressure. | 56 |
| 34771646 | 2021 | Towards Raman-Based Screening of Acute Lymphoblastic Leukemia-Type B (B-ALL) Subtypes. | 56 |
| 34871373 | 2022 | Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy. | 55 |
| 38338754 | 2024 | CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL. | 54 |
| 34933343 | 2022 | Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001. | 53 |
| 37704696 | 2023 | Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment. | 53 |
| 36848637 | 2023 | Classification and genetics of pediatric B-other acute lymphoblastic leukemia by targeted RNA sequencing. | 53 |
| 39008716 | 2024 | A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL. | 52 |
| 33646306 | 2021 | Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia. | 52 |
| 35562965 | 2022 | Multi-Cohort Transcriptomic Subtyping of B-Cell Acute Lymphoblastic Leukemia. | 49 |
| 36233173 | 2022 | Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia. | 47 |
| 34250504 | 2021 | Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy. | 46 |
| 19713226 | 2010 | Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. | 46 |
| 36124444 | 2023 | Clinical features and outcomes of fusion gene defined adult Ph-negative B-cell precursor acute lymphoblastic leukemia patients: A single institutional report. | 45 |
| 38598725 | 2024 | Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL. | 44 |
| 37305720 | 2023 | Comprehensive genetic analyses of childhood acute leukemia in Iraq using next-generation sequencing. | 44 |
| 37981088 | 2024 | Transcriptome Sequencing Allows Comprehensive Genomic Characterization of Pediatric B-Acute Lymphoblastic Leukemia in an Academic Clinical Laboratory. | 43 |
| 39261601 | 2024 | Determinants of survival after first relapse of acute lymphoblastic leukemia: a Children's Oncology Group study. | 41 |
| 35084434 | 2022 | Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia. | 41 |
| 35685921 | 2022 | Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population. | 40 |
| 31305009 | 2019 | Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy. | 38 |
| 32984014 | 2020 | A Nomogram for the Prediction of Progression and Overall Survival in Childhood Acute Lymphoblastic Leukemia. | 38 |
| 33663097 | 2021 | Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling: A case report and literature review. | 37 |
| 38546916 | 2024 | Extracellular matrix protein 1 (ECM1) is a potential biomarker in B cell acute lymphoblastic leukemia. | 36 |
| 27461063 | 2017 | Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia. | 32 |
| 30369727 | 2018 | Keeping PACE with Ph Positive to Ph-Like Detection in B-Lineage Acute Lymphoblastic Leukemia: A Practical and Cost Effective (PACE) Approach in a Resource Constrained Setting. | 32 |
| 36624786 | 2022 | Prognostic significance of steroid response in pediatric acute lymphoblastic leukemia: The CCCG-ALL-2015 study. | 32 |
| 30487223 | 2018 | Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. | 31 |
| 38023200 | 2023 | Retrospective analysis of outcomes for pediatric acute lymphoblastic leukemia in South American centers. | 31 |
| 32955970 | 2021 | Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia - a distinct subtype with favorable prognosis. | 30 |
| 34617433 | 2022 | Characterization of Immunophenotypic Aberrancies with Respect to Common Fusion Transcripts in B-Cell Precursor Acute Lymphoblastic Leukemia: A Report of 986 Indian Patients. | 29 |
| 32563910 | 2020 | Ibrutinib is not an effective drug in primografts of TCF3-PBX1. | 27 |
| 34553842 | 2022 | Genetic features of B-cell lymphoblastic lymphoma with TCF3-PBX1. | 27 |
| 32882024 | 2021 | Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children. | 25 |
| 30510082 | 2019 | Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. | 25 |
| 36114009 | 2022 | Extended vincristine and dexamethasone pulse therapy may not be necessary for children with TCF3-PBX1 positive acute lymphoblastic leukaemia. | 23 |
| 31575852 | 2019 | Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion. | 23 |
| 31434706 | 2019 | The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns. | 22 |
| 35125724 | 2022 | Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience. | 20 |
| 30262566 | 2019 | B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene. | 19 |
| 24578304 | 2014 | Outcome of TCF3-PBX1 positive pediatric acute lymphoblastic leukemia patients in Japan: a collaborative study of Japan Association of Childhood Leukemia Study (JACLS) and Children's Cancer and Leukemia Study Group (CCLSG). | 17 |
| 24135088 | 2013 | Translocation junctions in TCF3-PBX1 acute lymphoblastic leukemia/lymphoma cluster near transposable elements. | 17 |
| 30563523 | 2018 | A novel PAX5 rearrangement in TCF3-PBX1 acute lymphoblastic leukemia: a case report. | 17 |
| 38426288 | 2024 | Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. | 15 |
| 35845183 | 2021 | Cytogenetic aberrations in adult acute lymphoblastic leukemia-A population-based study. | 15 |
| 25729575 | 2015 | A (1;19) translocation involving TCF3-PBX1 fusion within the context of a hyperdiploid karyotype in adult B-ALL: a case report and review of the literature. | 14 |
| 35782267 | 2022 | (18)F-FDG PET/CT for the detection of extensive bone relapse in acute lymphoblastic leukemia with TCF3-PBX1 fusion after hematopoietic stem cell transplantation. | 5 |
| 37120350 | 2023 | Emerging molecular subtypes and therapies in acute lymphoblastic leukemia. | 0 |
| 38106088 | 2023 | SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA. | 0 |
| 37407363 | 2023 | Transcription factor abnormalities in B-ALL leukemogenesis and treatment. | 0 |
| 29334255 | 2018 | NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia. | 0 |
| 30051646 | 2018 | Excellent outcome of acute lymphoblastic leukaemia with TCF3-PBX1 rearrangement in Hong Kong. | 0 |
| 34034913 | 2021 | Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China. | 0 |
| 28436581 | 2017 | Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan. | 0 |
| 33221150 | 2021 | Long-Term Results of the Risk-Stratified Treatment of TCF3-PBX1-Positive Pediatric Acute Lymphoblastic Leukemia in China. | 0 |
| 27431573 | 2016 | Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review). | 0 |
| 39306917 | 2024 | Dysregulation of metallothionein MT1 sub-types in TCF3::PBX1 pre-B-cell acute lymphoblastic leukemia. | 0 |
| 37058324 | 2023 | TCF3 gene rearrangements in pediatric B-cell acute lymphoblastic leukemia-A single center experience. | 0 |
| 36943767 | 2023 | Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study. | 0 |
| 34549416 | 2022 | Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable residual disease-oriented protocols. | 0 |
| 17593026 | 2007 | Characterisation of genomic translocation breakpoints and identification of an alternative TCF3/PBX1 fusion transcript in t(1;19)(q23;p13)-positive acute lymphoblastic leukaemias. | 0 |
| 30631148 | 2019 | Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting. | 0 |
| 34460133 | 2022 | Cryptic TCF3 fusions in childhood leukemia: Detection by RNA sequencing. | 0 |
| 38663165 | 2024 | Real world outcome of B ALL with t (1; 19) (q23; p13)/TCF3::PBX1 in adolescents and adults treated with intensive regimes. | 0 |
| 28709134 | 2017 | BCR-ABL1-like acute lymphoblastic leukaemia: From bench to bedside. | 0 |
| 38719770 | 2024 | Evaluation of next-generation sequencing for measurable residual disease monitoring in three major fusion transcript subtypes of B-precursor acute lymphoblastic leukaemia. | 0 |
| 18024406 | 2007 | Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children. | 0 |
| 37819686 | 2024 | A surrogate molecular approach for the detection of Philadelphia chromosome-like B-acute lymphoblastic leukemia. | 0 |
| 25551271 | 2015 | Clinical features and prognostic significance of TCF3-PBX1 fusion gene in Chinese children with acute lymphoblastic leukemia by using a modified ALL-BFM-95 protocol. | 0 |
| 33283706 | 2020 | [The Correlation of Minimal Residual Disease with Prognosis in TCF3-PBX1(+) Acute Lymphoblastic Leukemia in Children]. | 0 |
| 21534874 | 2011 | Prognostic impact of t(1;19)/ TCF3-PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin-Frankfurt-Münster-based protocols. | 0 |
| 39266021 | 2024 | Case of B-acute lymphoblastic leukaemia with t(1;19)(q23;p13.3) TCF3::PBX1 and co-occurring CBL mutation in an elderly patient. | 0 |
| 37846676 | 2023 | [Clinical Significance of Minimal Residual Disease in Pediatric Patients with TCF3/PBX1(+) B-cell Acute Lymphoblastic Leukemia]. | 0 |
| 35092653 | 2022 | MicroRNA gene methylation landscape in pediatric B-cell precursor acute lymphoblastic leukemia. | 0 |
| 20302770 | 2010 | [A clinical and laboratory study of TCF3-PBX1 positive adult acute lymphoblastic leukemia.]. | 0 |
| 34597466 | 2022 | Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse. | 0 |
| 34325057 | 2021 | Comparison of Two Quantitative PCR-Based Assays for Detection of Minimal Residual Disease in B-Precursor Acute Lymphoblastic Leukemia Harboring Three Major Fusion Transcripts. | 0 |
| 38407197 | 2024 | TCF3::PBX1 fusion pediatric B acute lymphoblastic leukemia in disguise behind the eyes - an unusual clinicopathologic presentation with hyperdiploid clone. | 0 |
| 23859904 | 2013 | Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1, and MLL-AFF1 fusion genes in Guatemalan pediatric acute lymphoblastic leukemia patients and their ethnic associations. | 0 |
| 17311319 | 2007 | Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia. | 0 |
| 34049715 | 2021 | Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis. | 0 |
| 33386596 | 2021 | The role of minimal residual disease in specific subtypes of pediatric acute lymphoblastic leukemia. | 0 |
| 27698447 | 2017 | Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children. | 0 |
| 36044298 | 2023 | Clinical and Cytogenetic Characteristics of Children With Leukemia 20-Year Retrospective Study. | 0 |
| 31828595 | 2020 | Multiple heterogeneous bone invasions of B lymphoblastic lymphoma with the TCF3/PBX1 fusion gene: a case report. | 0 |
| 37594294 | 2023 | BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3. | 0 |
| 36550642 | 2022 | Cytogenetic Profile Of Acute Lymphoblastic Leukaemia Patients And Its Association With Induction Remission Status. | 0 |
| 35344469 | 2022 | Adult acute lymphoblastic leukemia in a resource-constrained setting: outcomes after expansion of genetic evaluation. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 19713226 | 2010 | Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. | Burmeister T et al |
| 14508819 | 2003 | The biology and therapy of adult acute lymphoblastic leukemia. | Faderl S et al |
| 21534874 | 2011 | Prognostic impact of t(1;19)/ TCF3-PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin-Frankfurt-Münster-based protocols. | Felice MS et al |
| 12094248 | 2002 | Antigen expression patterns reflecting genotype of acute leukemias. | Hrusák O et al |
| 8608207 | 1996 | Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. | Hunger SP et al |
| 1967983 | 1990 | A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. | Kamps MP et al |
| 7910944 | 1994 | Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. | Lu Q et al |
| 2078515 | 1990 | Molecular analysis of the t(1;19) breakpoint cluster region in pre-B cell acute lymphoblastic leukemias. | Mellentin JD et al |
| 1682799 | 1991 | PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. | Monica K et al |
| 1967982 | 1990 | Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. | Nourse J et al |
| 15744350 | 2005 | Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. | Prima V et al |
| 1348433 | 1992 | Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. | Privitera E et al |
| 9718381 | 1998 | Acute lymphoblastic leukemia. | Pui CH et al |
| 7989935 | 1994 | Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23; p13) or its derivative. | Pui CH et al |
| 1593901 | 1992 | Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia. | Secker-Walker LM et al |
| 7734349 | 1995 | Heterogeneity of t(1;19)(q23;p13) acute leukaemias. French Haematological Cytology Group. | Troussard X et al |
| 9469337 | 1998 | Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group. | Uckun FM et al |
Summary
Fusion gene
TCF3/PBX1 TCF3 (19p13.3) PBX1 (1q23.3) COF 1489 1490 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 2137 2138 2140 2141 2142 2143 2144 2145 2146 2147|TCF3/PBX1 TCF3 (19p13.3) PBX1 (1q23.3) M der(19)t(1;19)(q23;p13) t(1;19)(q23;p13)|TCF3/PBX1 TCF3 (19p13.3) PBX1 (1q23.3) TIC
Note
Balanced form: -1, -19, +der(1), +der(19); unbalanced form: -19, +der(19).
t(1;19)(q23;p13) TCF3/PBX1 (A): Unbalanced form: der(19) t(1;19)(q23;p13) G-banding; top - Courtesy Jean-Luc Lai; others - Courtesy Adriana Zamecnikova; and R-banding; top: - Jean Loup Huret, below: - Courtesy Christiane Charrin. (B): Balanced form: t(1;19)(q23;p13) - Courtesy Jean-Luc Lai; bottom: - Courtesy Adriana Zamecnikova. Fluorescence in situ hybridization on metaphases using the LSI TCF3/PBX1 Dual Color, Dual Fusion Translocation Probe (Vysis/Abbott Molecular, US) on (C): normal metaphase and confirming the presence of the TCF3-PBX1 gene fusion on (D): unbalanced der(19)t(1;19)(q23;p13.3) or (E): balanced t(1;19)(q23;p13) - Courtesy Adriana Zamecnikova.
Citation
Cristina N Alonso
t(1;19)(q23;p13) TCF3/PBX1
Atlas Genet Cytogenet Oncol Haematol. 2012-07-01
Online version: http://atlasgeneticsoncology.org/haematological/1048/t(1
Historical Card
1997-10-01 t(1;19)(q23;p13) TCF3/PBX1 by Jean-Loup Huret Affiliation
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers France
