t(10;11)(p12;q21) PICALM/MLLT10

1998-01-01   Jean-Loup Huret , Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


a mainly T-cell ALL; at times AML and/or AML with T-cellcommon progenitor may be involved; FAB: L1/L2

Phenotype stem cell origin

a myelomonocytic/T- cell


< 1% of ALL; about 5 % of T-ALL; sex ratio: 9M/5F (from 14 cases herein reviewed)


organomegaly; no CNS involvement; blood data: high WBC (range 20-170 X 109/l)


median survival: 22 mths in this review; range: 0-33+ mths, n=11(but we are to be cautious: cases ascertained by molecular studies areneeded before true prognostic ascertainment)


Cytogenetics molecular

investigations are required

Additional anomalies

most often (11/15 cases) present; del(5q), +8, and +19already recurrent

Genes Involved and Proteins

Gene name
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Dna rna description
5 telomeric --> 3 centromeric orientation
Protein description
contains 3 Zn fingezrs and a leucine zipper; nuclearlocalisation; transcription factor
Gene name
PICALM (clathrin assembly lymphoid myeloid leukemia gene)
Protein description
role in the integration of different signals;

Result of the Chromosomal Anomaly


both 5 CALM - 3 AF10 and 5 AF10 - 3 CALM are expressed


1- a 1595 amino acids protein with N-term and most of CALM(except the last 4 amino acids!) fused to most of AF10 from amino acid 81(excluding the N-term zinc finger of AF10) C-term; 2- and a small 84 aminoacids protein with N-term zinc finger from AF10 fused to the very C-termend of CALM


it is not known which of the 2 fusion protein has the critical role

Highly cited references

Pubmed IDYearTitleCitations
236738602013New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.25
158438272005Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.23
238319222013The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.19
236702962013Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia.13
228714732012PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.13
309147382019Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.11
208758752010Acute leukemia with PICALM-MLLT10 fusion gene: diagnostic and treatment struggle.9
222358512012EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.8
317391262020Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens.3
350822692022Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins.1
333175672020Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability.1
302273972018Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene.1
165188482006Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9.1
334894532020Fatal hyperleukocytic T lymphoblastic lymphoma/leukemia complicated with multi-gene fusion and mutation: clinical revelation and perception.0
291895092018Successful Treatment of a Very Late Isolated Relapse in an Adolescent With a PICALM-MLLT10 Positive T-lineage Acute Lymphoblastic Leukemia.0


No bibliography items were found for this article.


Fusion gene

PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) M t(10;11)(p12;q14) t(10;11)(p12;q23) t(10;19;11)(p12;p13;q14) t(9;11)(p12;q14)|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TF LAML|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TIC


the description opf this rare entity is arduous, since cases without molecular studies can be confused with cases of t(10;11)(p12;q23)
Atlas Image
t(10;11)(p13;q21) G-banding (top 2) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; middle row: - Courtesy Catherine Roche-Lestienne. R-banding (bottom 2) and Fish studies with MLL probe showing a signal on the normal 11 and one on the der(10) (right) and with chromosome 11 paint - Courtesy Pascale Cornillet-Lefebvre and Stéphanie Struski.


Jean-Loup Huret ; Jean-Loup Huret

t(10;11)(p12;q21) PICALM/MLLT10

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1067/t(10;11)(p12;q21)