t(10;11)(p12;q23) KMT2A/MLLT10

1997-12-01   Jean-Loup Huret , Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

AML

Phenotype stem cell origin

M5/M4; ALL at times, therapy related cases

Epidemiology

from infants to adults

Prognosis

poor

Cytogenetics

Cytogenetics morphological

A high diversity of reported breakpoints onchromosome 10, from 10p11 to 10p15: remains to be fully studiedL

Additional anomalies

inv(11)(q13q23) is frequently acompanying thet(10;11); this is likely to be related to the transcription directions ofthe two genes

Genes Involved and Proteins

Gene name
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Location
10p12.31
Dna rna description
5 telomeric --> 3 centromeric orientation
Protein description
contains 3 Zn fingezrs and a leucine zipper; nuclearlocalisation; transcription factor , and Zinc fingers), a DNA methyl transferase motif, a bromodomain; , transcriptional regulatory factor; nuclear localisation
Gene name
KMT2A (myeloid/lymphoid or mixed lineage leukemia)
Location
11q23.3
Dna rna description
21 exons, spanning over 100 kb; 13-15 kb mRNA
Protein description
431 kDa; contains two DNA binding motifs (a AT hook,

Result of the Chromosomal Anomaly

Description

5 MLL - 3 AF10; variable breakpoints on both chromosomes; thefusion transcript on chromosome 11 is the crucial one; MLL and AF10 are inopposite transcriptional directions, wich may be cause of the complexity ofthe translocationN-term AT hook and DNA methyltransferase from MLL fused to theleucine zipper C-term of AF10

Expression localisation

nuclear localisation

Bibliography

No bibliography items were found for this article.

Summary

Fusion gene

KMT2A/MLLT10 KMT2A (11q23.3) MLLT10 (10p12.31) COF 2033 2034 2035 2036 2037 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052|KMT2A/MLLT10 KMT2A (11q23.3) MLLT10 (10p12.31) TIC

Citation

Jean-Loup Huret ; Jean-Loup Huret

t(10;11)(p12;q23) KMT2A/MLLT10

Atlas Genet Cytogenet Oncol Haematol. 1997-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1025/t(10;11)(p12;q23)-kmt2a-mllt10

External Links