t(10;11)(p12;q23) KMT2A/MLLT10
1997-12-01 Jean-Loup Huret , Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
AML
Phenotype stem cell origin
M5/M4; ALL at times, therapy related cases
Epidemiology
from infants to adults
Prognosis
poor
Cytogenetics
Cytogenetics morphological
A high diversity of reported breakpoints onchromosome 10, from 10p11 to 10p15: remains to be fully studiedL
Additional anomalies
inv(11)(q13q23) is frequently acompanying thet(10;11); this is likely to be related to the transcription directions ofthe two genes
Genes Involved and Proteins
Gene name
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Location
10p12.31
Dna rna description
5 telomeric --> 3 centromeric orientation
Protein description
contains 3 Zn fingezrs and a leucine zipper; nuclearlocalisation; transcription factor
Gene name
KMT2A (myeloid/lymphoid or mixed lineage leukemia)
Location
11q23.3
Dna rna description
21 exons, spanning over 100 kb; 13-15 kb mRNA
Protein description
431 kDa; contains two DNA binding motifs (a AT hook,
Protein description
and Zinc fingers), a DNA methyl transferase motif, a bromodomain;
Protein description
transcriptional regulatory factor; nuclear localisation
Result of the Chromosomal Anomaly
Description
5 MLL - 3 AF10; variable breakpoints on both chromosomes; thefusion transcript on chromosome 11 is the crucial one; MLL and AF10 are inopposite transcriptional directions, wich may be cause of the complexity ofthe translocationN-term AT hook and DNA methyltransferase from MLL fused to theleucine zipper C-term of AF10
Expression localisation
nuclear localisation
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37019972 | 2023 | Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication. | 71 |
| 38086945 | 2024 | Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia. | 49 |
| 38306602 | 2024 | Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia. | 40 |
| 37942413 | 2023 | A scoring system based on fusion genes to predict treatment outcomes of the non-acute promyelocytic leukemia pediatric acute myeloid leukemia. | 38 |
| 38621200 | 2024 | Optimized cytogenetic risk-group stratification of KMT2A-rearranged pediatric acute myeloid leukemia. | 35 |
| 34572762 | 2021 | Advances in the First Line Treatment of Pediatric Acute Myeloid Leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019. | 33 |
| 38162585 | 2024 | Acute myeloid leukemia cutis with KMT2A::MLLT3 fusion presenting with leonine facies. | 10 |
| 29445560 | 2017 | The Partial Duplication of the 5' Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia. | 7 |
| 30707474 | 2019 | Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory. | 0 |
| 37478796 | 2023 | Cryptic KMT2A/MLLT10 fusion detected by next-generation sequencing in a case of pediatric acute megakaryoblastic leukemia. | 0 |
| 36774707 | 2023 | Unexpected appearance of KMT2A::MLLT10 fusion transcript in acute myeloid leukemia with t(5;11)(q31;q23.3). | 0 |
| 38740515 | 2024 | Personalized therapy guided by single-cell transcriptomic analysis in relapsed and refractory KMT2A::MLLT10 AML with extensive extramedullary infiltration: A case report. | 0 |
| 37248168 | 2023 | Acute monocytic leukemia with KMT2A:MLLT10 transformed to AML-M7 in a pediatric patient. | 0 |
| 39743677 | 2025 | Cryptic KMT2A::MLLT10 Rearrangement in a Highly Aggressive Acute Myeloid Leukemia. | 0 |
| 30624859 | 2019 | Acute myeloid leukemia with t(10;11)(p11-12;q23.3): Results of Russian Pediatric AML registration study. | 0 |
| 34551411 | 2022 | Adult Acute Myeloid Leukemia with the KMT2A-Mixed Lineage Leukemia T10 Fusion: An Analysis of 10 Cases Showed Common Features and Frequent Mutations in the RAS Signaling Pathway. | 0 |
| 35978554 | 2022 | A rare case of transformation from relapsed acute monocytic leukaemia with KMT2A::MLLT10 to acute megakaryoblastic leukaemia. | 0 |
| 30277115 | 2019 | Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients. | 0 |
| 30203571 | 2018 | KMT2A (MLL) rearrangements observed in pediatric/young adult T-lymphoblastic leukemia/lymphoma: A 10-year review from a single cytogenetic laboratory. | 0 |
| 28921816 | 2018 | Comprehensive genetic analysis of donor cell derived leukemia with KMT2A rearrangement. | 0 |
| 30273780 | 2019 | Accurate and Sensitive Analysis of Minimal Residual Disease in Acute Myeloid Leukemia Using Deep Sequencing of Single Nucleotide Variations. | 0 |
| 39802758 | 2024 | Successful classification of clinical pediatric leukemia genetic subtypes via structural variant detection using HiFi long-read sequencing. | 0 |
Bibliography
No bibliography items were found for this article.
Summary
Fusion gene
KMT2A/MLLT10 KMT2A (11q23.3) MLLT10 (10p12.31) COF 2033 2034 2035 2036 2037 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052|KMT2A/MLLT10 KMT2A (11q23.3) MLLT10 (10p12.31) TIC
Citation
Jean-Loup Huret ; Jean-Loup Huret
t(10;11)(p12;q23) KMT2A/MLLT10
Atlas Genet Cytogenet Oncol Haematol. 1997-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1025/new-content/
