2008-11-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Myeloid disorders: myelodysplastic syndromes (MDS) and acute myeloid leukaemias (AML)

Phenotype stem cell origin

The AML case was a myelomonocytic leukaemia (M4-AML) with eosinophilia; one of the the MDS cases also showed bone marrow eosinophilia. One MDS case was treatment related (t-MDS), the first tumour was a mantle cell lymphoma.


Only 3 cases to date, 1 male and 2 female patients, aged 47, 59, and 63 years (Neri et al., 1985; Bernard et al., 1989; Olney et al., 2002).

Genes Involved and Proteins

The genes involved are unknown; because of the eosinophilia in at least 2 of 3 patients, it is likely that the gene involved in 16q22 is CBFB.


Pubmed IDLast YearTitleAuthors
27792891989Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases.Bernard P et al
39672111985Chromosome 16q, eosinophilia, and leukemia.Neri G et al
119212752002Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.Olney HJ et al


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2008-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1088/t(3;16)(q21;q22)