t(3;5)(q21;q31)

2013-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative disorder (MPD)

Note

26 cases of t(3;5)(q21;q31) in myeloid malignancy are available (Oshimura et al., 1976; Dewald, 1984; Bitter et al., 1985; Testa et al., 1985; Werner-Favre et al., 1985; Pi and Kalousek, 1986; Smadja et al., 1986; McCarthy et al., 1987; Sharp et al., 1987; Akiyoshi et al., 1991; Katz et al., 1992; Solé et al., 1992; Secker-Walker et al., 1995; Wong and Kwong, 1995; Groupe Français de Cytogénétique Hématologique, 1996; Dong et al., 1998; Mazzella et al., 1998; Misawa et al., 1998; Green et al., 1999; Berger et al., 2006; Lugthart et al., 2010). We have excluded from this review a case of acute lymphoblastic leukemia (Chen et al., 1992).

Phenotype stem cell origin

There was 5 M6-AMLs, 2 M4-AMLs, 10 M2-AMLs, and 6 AMLs not otherwise specified (AML-NOS), 1 myeloid metaplasia with myelofibrosis (MMM) in acute phase, another myeloproliferative syndrome not otherwise specified, and a refractory anemia with excess of blasts in transformation (RAEB-t). There was no reference with a previous toxic exposure.

Epidemiology

Median age was 36-38 years (range 3-85, with two pediatric cases aged 3); sex ratio was 11M/14F.

Prognosis

Data on survival is very scarce (patients alive at 3 months, 21 months, 29 months, and 30 months; and patients dead at 7 and 9 months).

Genes Involved and Proteins

Note
The genes involved in this translocation remain unknown.

Bibliography

Pubmed IDLast YearTitleAuthors
16544801991Genotypic and cytogenetic study of acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis: specific delta rearrangement pattern does not involve J delta gene locus.Akiyoshi TT et al
163410352006Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements.Berger R et al
40635251985Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia.Bitter MA et al
16384751992Non-random involvement of chromosome 5 in ALL.Chen Z et al
95654631998Translocation(3;5)(q21-24;q31-34) in two cases of acute myeloid leukemia and in one case of thrombocytosis.Dong SY et al
106024161999Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31).Green WB et al
15812121992Possible evidence for genomic imprinting in childhood acute myeloblastic leukaemia associated with monosomy for chromosome 7.Katz F et al
206608332010Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia.Lugthart S et al
98023431998Acute erythroleukemia: evaluation of 48 cases with reference to classification, cell proliferation, cytogenetics, and prognosis.Mazzella FM et al
34751671987Sweet's syndrome, acute leukemia, and t(3;5).McCarthy CM et al
96801141998Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia.Misawa S et al
10678911976Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML).Oshimura M et al
34558561986Translocation t(3;5) in acute myelocytic leukemia type M2.Pi D et al
85471011995Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study.Secker-Walker LM et al
34755141987t(3;5)(q21;q31) in a myelodysplastic syndrome.Sharp RA et al
39430591986Translocation t(3;5) and acute nonlymphocytic leukemia.Smadja N et al
16065541992Cytogenetic studies in acute nonlymphocytic leukemia.Solé F et al
38552851985Chromosomal alterations in acute leukemia patients studied with improved culture methods.Testa JR et al
39785961985Translocation t(3;5) in ANLL.Werner-Favre C et al
76682371995Complex variant t(3;5) (q21;q31), t(3;5;19)(q21;q31;p13) in acute myeloid leukemia.Wong KF et al
89319991996Cytogenetic analysis in patients with primary myelodysplastic syndromes in leukaemic transformation. A report on 94 cases. Groupe Français de Cytogénétique Hématologique (GFCH).

Summary

Atlas Image
t(3;5)(q21;q31). G- banding (left) - top three: Courtesy Christine Perot; middle/bottom: Courtesy Francine Mugneret; bottom (RBA banding): Lucienne Michaux and Peter Vandenberghe; and R- banding (right) - top three: Courtesy Christine Perot; bottom three: Courtesy Francine Mugneret.

Citation

Jean-Loup Huret

t(3;5)(q21;q31)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1110/t(3;5)(q21;q31)

External Links