2013-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative disorder (MPD)


26 cases of t(3;5)(q21;q31) in myeloid malignancy are available (Oshimura et al., 1976; Dewald, 1984; Bitter et al., 1985; Testa et al., 1985; Werner-Favre et al., 1985; Pi and Kalousek, 1986; Smadja et al., 1986; McCarthy et al., 1987; Sharp et al., 1987; Akiyoshi et al., 1991; Katz et al., 1992; Solé et al., 1992; Secker-Walker et al., 1995; Wong and Kwong, 1995; Groupe Français de Cytogénétique Hématologique, 1996; Dong et al., 1998; Mazzella et al., 1998; Misawa et al., 1998; Green et al., 1999; Berger et al., 2006; Lugthart et al., 2010). We have excluded from this review a case of acute lymphoblastic leukemia (Chen et al., 1992).

Phenotype stem cell origin

There was 5 M6-AMLs, 2 M4-AMLs, 10 M2-AMLs, and 6 AMLs not otherwise specified (AML-NOS), 1 myeloid metaplasia with myelofibrosis (MMM) in acute phase, another myeloproliferative syndrome not otherwise specified, and a refractory anemia with excess of blasts in transformation (RAEB-t). There was no reference with a previous toxic exposure.


Median age was 36-38 years (range 3-85, with two pediatric cases aged 3); sex ratio was 11M/14F.


Data on survival is very scarce (patients alive at 3 months, 21 months, 29 months, and 30 months; and patients dead at 7 and 9 months).

Genes Involved and Proteins

The genes involved in this translocation remain unknown.


Pubmed IDLast YearTitleAuthors
16544801991Genotypic and cytogenetic study of acute myelocytic leukemia and chronic myelocytic leukemia in blast crisis: specific delta rearrangement pattern does not involve J delta gene locus.Akiyoshi TT et al
163410352006Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements.Berger R et al
40635251985Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia.Bitter MA et al
16384751992Non-random involvement of chromosome 5 in ALL.Chen Z et al
95654631998Translocation(3;5)(q21-24;q31-34) in two cases of acute myeloid leukemia and in one case of thrombocytosis.Dong SY et al
106024161999Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31).Green WB et al
15812121992Possible evidence for genomic imprinting in childhood acute myeloblastic leukaemia associated with monosomy for chromosome 7.Katz F et al
206608332010Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia.Lugthart S et al
98023431998Acute erythroleukemia: evaluation of 48 cases with reference to classification, cell proliferation, cytogenetics, and prognosis.Mazzella FM et al
34751671987Sweet's syndrome, acute leukemia, and t(3;5).McCarthy CM et al
96801141998Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia.Misawa S et al
10678911976Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML).Oshimura M et al
34558561986Translocation t(3;5) in acute myelocytic leukemia type M2.Pi D et al
85471011995Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study.Secker-Walker LM et al
34755141987t(3;5)(q21;q31) in a myelodysplastic syndrome.Sharp RA et al
39430591986Translocation t(3;5) and acute nonlymphocytic leukemia.Smadja N et al
16065541992Cytogenetic studies in acute nonlymphocytic leukemia.Solé F et al
38552851985Chromosomal alterations in acute leukemia patients studied with improved culture methods.Testa JR et al
39785961985Translocation t(3;5) in ANLL.Werner-Favre C et al
76682371995Complex variant t(3;5) (q21;q31), t(3;5;19)(q21;q31;p13) in acute myeloid leukemia.Wong KF et al
89319991996Cytogenetic analysis in patients with primary myelodysplastic syndromes in leukaemic transformation. A report on 94 cases. Groupe Français de Cytogénétique Hématologique (GFCH).


Atlas Image
t(3;5)(q21;q31). G- banding (left) - top three: Courtesy Christine Perot; middle/bottom: Courtesy Francine Mugneret; bottom (RBA banding): Lucienne Michaux and Peter Vandenberghe; and R- banding (right) - top three: Courtesy Christine Perot; bottom three: Courtesy Francine Mugneret.


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1110/t(3;5)(q21;q31)