t(5;14)(q31;q32) IGH/IL3
1999-12-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Phenotype stem cell origin
CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)
Epidemiology
rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age
Cytology
marked eosinophilia; basophilia; IL3 is over-expressed
Prognosis
prognosis appears to be poor, a feature of ALLs with hypereosinophilia
Genes Involved and Proteins
Gene name
IL3 (interleukin-3)
Location
5q31.1
Protein description
152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33
Result of the Chromosomal Anomaly
Description
break in the promoter region of IL3 and in the Jh region of IgH
Expression localisation
the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis
over-expression of IL3
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31921638 | 2019 | B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL. | 41 |
| 37120350 | 2023 | Emerging molecular subtypes and therapies in acute lymphoblastic leukemia. | 0 |
| 33991782 | 2021 | Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 2508400 | 1989 | Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity? | Baumgarten E et al |
| 1638475 | 1992 | Non-random involvement of chromosome 5 in ALL. | Chen Z et al |
| 2374508 | 1990 | Acute lymphoblastic leukemia with eosinophilia. | Fishel RS et al |
| 2499362 | 1989 | The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. | Grimaldi JC et al |
| 1564954 | 1992 | Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia. | Heerema NA et al |
| 3546615 | 1987 | Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review. | Hogan TF et al |
| 7512364 | 1993 | Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14). | Knuutila S et al |
| 3479532 | 1987 | Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome. | McConnell TS et al |
| 2114933 | 1990 | Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. | Meeker TC et al |
| 6583469 | 1984 | Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]. | Tono-oka T et al |
Summary
Fusion gene
IGH/IL3 IGH (14q32.33) IL3 (5q31.1) M t(5;14)(q31;q32)
t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.
Citation
Jean-Loup Huret
t(5;14)(q31;q32) IGH/IL3
Atlas Genet Cytogenet Oncol Haematol. 1999-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1111/t(5
