t(1;5)(p32;q31) ?/TAL1

1998-09-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

T cell acute lymphocytic leukaemia (T-ALL)

Clinics

yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths +

Genes Involved and Proteins

Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene name
yet unknown gene
Location
5q31

Result of the Chromosomal Anomaly

Description

breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3, within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions.

Expression localisation

high nuclear expression

Highly cited references

Pubmed IDYearTitleCitations
205667372010Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.167
212824672011Role of helix-loop-helix proteins during differentiation of erythroid cells.155
355149542022E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.133
290342062017Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia.123
343480002021Role of GATA2 in Human NK Cell Development.115
384220192024Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program.99
263566742015The search for cis-regulatory driver mutations in cancer genomes.97
284108822017Epo reprograms the epigenome of erythroid cells.89
372132352023RUNX1 colludes with NOTCH1 to reprogram chromatin in T cell acute lymphoblastic leukemia.87
360445732022Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2.82
375952782023Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs.81
356493762022Differential Etv2 threshold requirement for endothelial and erythropoietic development.78
242901922014Ldb1 complexes: the new master regulators of erythroid gene transcription.75
268825642016microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia.74
332936322020The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis.74
200289762010Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.71
319806092020Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing.70
297135152018The Role of TAL1 in Hematopoiesis and Leukemogenesis.70
320865282020Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.69
248745752014PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.69
349339392022Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers.68
211790042011Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.68
240759072013tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium.65
208554952010NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.62
397164912025ID3 promotes erythroid differentiation and is repressed by a TAL1-PRMT6 complex.62
320490462020Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.61
373793222023Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.61
236982772014Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.60
223102832012Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.59
307874362019A single-cell molecular map of mouse gastrulation and early organogenesis.57
362170162022Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.56
343607892021A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.56
355085112022The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.54
269446782016UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.54
177229832007Early endocardial morphogenesis requires Scl/Tal1.54
265037822016Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution.52
238579842013The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.52
360735132023Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia.51
380582002024CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.50
296542722018Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.50
384994352024Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells.49
296328402016The proto-oncogenic protein TAL1 controls TGF-β1 signaling through interaction with SMAD3.48
368547502023TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.48
385535712024The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.47
382498882023Transcription factor-target gene regulatory network analysis in human lung adenocarcinoma.47
256154152015Site- and allele-specific polycomb dysregulation in T-cell leukaemia.44
353542482022TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia.43
166219692006Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.42
366327362023TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.41
295560242018The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.35
378550642024Regulatory mechanisms and context-dependent roles of TAL1 in T-cell acute lymphoblastic leukemia.33
368005762023Elevated STIL predicts poor prognosis in patients with hepatocellular carcinoma.32
240400982013SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution.31
319497922018A novel TAL1/miR-149* axis accelerates tumor growth of human T cell acute lymphoblastic leukemia.26
355633222022Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model.20
366504992023Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL.15
369488672023[Clinical features of 19 patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia].14
360450642023A Case of STIL-TAL1-positive T-lymphoblastic Leukemia With a Minor Philadelphia-positive Clone.11
381057392024ToTAL1y degraded - rapid dTAG proteolysis of TAL1 in T-cell acute lymphoblastic leukemia.11
390178472024Transcription Factor TAL1 in Erythropoiesis.0
381023372024Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.0
301457802019Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia.0
281792812017SCL/TAL1: a multifaceted regulator from blood development to disease.0
375919432023TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia.0
286799962017[Transcriptional regulation of erythropoiesis].0
334836152021T-ALL can evolve to oncogene independence.0
274432612016Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.0
375919402023S1P-S1PR3-RAS promotes the progression of S1PR3(hi) TAL1(+) T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist.0
81426191993TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia.0
96959591998TAL1 expression does not occur in the majority of T-ALL blasts.0
92306931997The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.0
314938712019TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway.0
369290522023Hematopoietic/erythroid enhancers activate nearby target genes by extending histone H3K27ac and transcribing intergenic RNA.0
242006852013Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL.0
273424902016[Clinical Characteristics and Treatment Efficacy of Children with SIL/TAL1 Positive T-Cell Acute Lymphoblastic Leukemia].0
164078362006p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.0
179621922008Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.0
258586762015The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.0
247921102014Targeting epigenetics to speed up repair.0
145820782003Gene expression profiling in T-cell acute lymphoblastic leukemia.0
286858912017Specification of neurotransmitter identity by Tal1 in thalamic nuclei.0
394886622024Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia.0
328355482020SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.0
255287282015KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus.0
74961601995TAL1 gene deletions and TAL1 protein expression in sporadic melanoma.0
179100692008Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12.0
381552452024Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.0
151932612004TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.0
219903712012Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.0
301854092018A novel role for Lyl1 in primitive erythropoiesis.0
104908301999p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein.0
159615172005SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.0
83506191993SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.0
159302672005Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity.0
195877032009Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1.0
167781722006Tal1 transgenic expression reveals absence of B lymphocytes.0
355691852022Hirsutine, a novel megakaryopoiesis inducer, promotes thrombopoiesis via MEK/ERK/FOG1/TAL1 signaling.0
197365202009Transcriptional regulation by TAL1: a link between epigenetic modifications and erythropoiesis.0
94050941997TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis.0
194069892009TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
97139951998Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia.François S et al

Citation

Jean-Loup Huret

t(1;5)(p32;q31) ?/TAL1

Atlas Genet Cytogenet Oncol Haematol. 1998-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1141/t(1;5)(p32;q31)