t(1;5)(p32;q31) ?/TAL1

1998-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

T cell acute lymphocytic leukaemia (T-ALL)

Clinics

yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths +

Genes Involved and Proteins

Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene name
yet unknown gene
Location
5q31

Result of the Chromosomal Anomaly

Description

breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3, within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions.

Expression localisation

high nuclear expression

Bibliography

Pubmed IDLast YearTitleAuthors
97139951998Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia.François S et al

Citation

Jean-Loup Huret

t(1;5)(p32;q31) ?/TAL1

Atlas Genet Cytogenet Oncol Haematol. 1998-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1141/t(1;5)(p32;q31)

External Links