t(1;5)(p32;q31) ?/TAL1

1998-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


T cell acute lymphocytic leukaemia (T-ALL)


yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths +

Genes Involved and Proteins

Gene name
TAL1 (T-cell acute leukemia 1)
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene name
yet unknown gene

Result of the Chromosomal Anomaly


breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3, within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions.

Expression localisation

high nuclear expression

Highly cited references

Pubmed IDYearTitleCitations
319806092020Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing.38
310189772020The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis.21
326323352020Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X.20
320490462020Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.19
309388202019Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.17
333240552020Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer.16
332596012020Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes.15
322313072020Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.15
330389822020Molecular markers in ALL: Clinical implications.9
320865282020Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.9
321276142020Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance.9
315461632019Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.8
344622612022Rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome shared megakaryocyte expansion in peripheral blood.6
317542152020Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.6
315019602019Deletion of PHO13 improves aerobic L-arabinose fermentation in engineered Saccharomyces cerevisiae.6
340754042021Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells.5
344545982021Rational engineering of Saccharomyces cerevisiae towards improved tolerance to multiple inhibitors in lignocellulose fermentations.5
340903362021Exposure to hypoxia causes stress erythropoiesis and downregulates immune response genes in spleen of mice.5
327169602020Metabolic engineering considerations for the heterologous expression of xylose-catabolic pathways in Saccharomyces cerevisiae.5
334765552021Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.4
336643682021Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).4
331870902020Regulating the Regulators: The Role of Histone Deacetylase 1 (HDAC1) in Erythropoiesis.4
323688312020Impact of immunophenotypic characteristics on genetic subgrouping in childhood acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) study L04-16.4
319962382020Vaccination accelerates hepatic erythroblastosis induced by blood-stage malaria.4
314938712019TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway.4
314194432019Identification of metabolism-associated pathways and genes involved in male and female liver cancer patients.4
347715552021SLUG and Truncated TAL1 Reduce Glioblastoma Stem Cell Growth Downstream of Notch1 and Define Distinct Vascular Subpopulations in Glioblastoma Multiforme.3
340397372021Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.3
337602142021HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis.3
329314872020Centrioles are amplified in cycling progenitors of olfactory sensory neurons.3
324133962020mRNA Profiling for miR-124-mediated Repair in Spinal Cord Injury.3
315825562020The dynamic emergence of GATA1 complexes identified in in vitro embryonic stem cell differentiation and in vivo mouse fetal liver.3
322295782020LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.3
326336352020MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia.3
315519762019Tal1NXtc01 in Xanthomonas translucens pv. cerealis Contributes to Virulence in Bacterial Leaf Streak of Wheat.3
349339392022Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers.2
334836152021T-ALL can evolve to oncogene independence.2
340748022021Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension.2
336376922021Regulation of MYB by distal enhancer elements in human myeloid leukemia.2
337913752021Identification of Critical Genes and lncRNAs in Osteolysis after Total Hip Arthroplasty and Osteoarthritis by RNA Sequencing.2
324156692021Hemovasculogenic origin of blood vessels in the developing mouse brain.2
332936322020The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis.2
328355482020SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.2
330533432020Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.2
325936722020The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2.2
316128832019Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells.2
354015012022Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.1
352051262022DRPPM-EASY: A Web-Based Framework for Integrative Analysis of Multi-Omics Cancer Datasets.1
342239282021CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia.1
337942232021Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds.1
344899252021Analysis of Bulk RNA Sequencing Data Reveals Novel Transcription Factors Associated With Immune Infiltration Among Multiple Cancers.1
324148552021Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia.1
338488092021Direct conversion of adult human fibroblasts into functional endothelial cells using defined factors.1
337889482021Effects of sheared chromatin length on ChIP-seq quality and sensitivity.1
337526002021The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo.1
332441172020Spontaneous intake of essential oils after a negative postnatal experience has long-term effects on blood transcriptome in chickens.1
330876952020ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem.1
332156722020Engineering sensitivity and specificity of AraC-based biosensors responsive to triacetic acid lactone and orsellinic acid.1
323171722020Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression.1
326530072020The influence of transketolase on lipid biosynthesis in the yeast Yarrowia lipolytica.1
324774632020Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2.1
322419092020Sterile α-motif domain requirement for cellular signaling and survival.1
321794112020PEST domain NOTCH mutations confer a poor relapse free survival in pediatric T-ALL: Data from a tertiary care centre in India.1
357683902022[Characteristics and prognostic effects of NOTCH1/FBXW7 gene mutations in T-cell acute lymphoblastic leukemia patients].0
360184582022Exploring prognostic value and regulation network of PPP1R1A in hepatocellular carcinoma.0
359635212022Sequential approach to improve the molecular classification of childhood acute lymphoblastic leukemia.0
359406862022Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish.0
342311012022Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis.0
358424742022Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endothelium.0
355691852022Hirsutine, a novel megakaryopoiesis inducer, promotes thrombopoiesis via MEK/ERK/FOG1/TAL1 signaling.0
356440222022Prognostic utility of key copy number alterations in T cell acute lymphoblastic leukemia.0
355633222022Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model.0
355149542022E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.0
353853572022Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases.0
353651822022A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis.0
356493762022Differential Etv2 threshold requirement for endothelial and erythropoietic development.0
355085112022The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.0
353542482022TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia.0
352633272022Increased ShTAL1 IgE responses post-Praziquantel treatment may be associated with a reduced risk to re-infection in a Ghanaian S. haematobium-endemic community.0
354291892022Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis.0
347245652022The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.0
353286122022The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.0
351408392022Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia.0
351632142022A Systematic Review of Circulatory microRNAs in Major Depressive Disorder: Potential Biomarkers for Disease Prognosis.0
351554252022STIL Acts as an Oncogenetic Driver in a Primary Cilia-Dependent Manner in Human Cancer.0
350468952021qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.0
347443392021Clinico-Hematological Profile and Copy Number Abnormalities in a Cohort of STIL-TAL1 and NUP214-ABL1 Positive Pediatric T-Cell Acute Lymphoblastic Leukemia.0
342172752021Hypodiploidy in a pediatric patient of T-cell acute lymphoblastic leukemia: a case report.0
343607892021A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.0
337976542021Multiple gene integration to promote erythritol production on glycerol in Yarrowia lipolytica.0
338584252021The biological function and clinical significance of STIL in osteosarcoma.0
343480002021Role of GATA2 in Human NK Cell Development.0
333339662020Outcomes in Pediatric Acute Lymphoblastic Leukemia-A Single-Center Romanian Experience.0
330769732020Correction to: MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1.0
323077502020Development of new dominant selectable markers for the nonconventional yeasts Ogataea polymorpha and Candida famata.0
324437262020Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish.0
325500992020Optimization of the l-tyrosine metabolic pathway in Saccharomyces cerevisiae by analyzing p-coumaric acid production.0
316966232020Combining proteomics and lipid analysis to unravel Confidor stress response in Saccharomyces cerevisiae.0
320272522020[Overexpression of Interferon Regulatory Factor IRF1 Remodels Homeostasis of K562 Cells].0
315940622019[Outcome of children with T cell acute lymphoblastic leukemia treated with Chinese Children Leukemia Group acute lymphoblastic leukemia (CCLG-ALL) 2008 protocol].0


Pubmed IDLast YearTitleAuthors
97139951998Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia.François S et al


Jean-Loup Huret

t(1;5)(p32;q31) ?/TAL1

Atlas Genet Cytogenet Oncol Haematol. 1998-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1141/t(1;5)(p32;q31)

External Links