dic(1;15)(p11;p11)
2007-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Myeloid malignancies
Phenotype stem cell origin
Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case.
Epidemiology
At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81)
Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235.
Prognosis
About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD).
Genes Involved and Proteins
Note
Genes involved are unknown; the translocation breakpoints are likely to be in heterochromatic regions
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
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Summary
dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai.
Citation
Jean-Loup Huret
dic(1;15)(p11;p11)
Atlas Genet Cytogenet Oncol Haematol. 2007-08-01
Online version: http://atlasgeneticsoncology.org/haematological/1159/dic(1
