t(1;18)(q25;q23)
1999-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
acute myeloid leukemia (AML) and acute lymphocycic leukemia (ALL)
Phenotype stem cell origin
M2 and M6AML, L2-ALL
Etiology
1 case was a therapy related AML, and the 2 other cases were found in Down syndrome (DS) patients
Epidemiology
poorly known: only 3 cases to date; 3 female patients aged 1-13 yrs
Prognosis
yet unknown : cases dead at 1 mth and alive at 2 mths+ (2 DS cases), alive at 12 mths+ (therapy related case)
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 2972356 | 1988 | Cytogenetic findings in leukemic cells of 56 patients with constitutional chromosome abnormalities. A cooperative study. Groupe Français de Cytogénétique Hématologique. | |
| 10214363 | 1999 | A second known case of Down syndrome with t(1;18)(q25;q23) in leukemic cells. | Brozek I et al |
| 2713498 | 1989 | Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse. | Hayashi Y et al |
Citation
Jean-Loup Huret
t(1;18)(q25;q23)
Atlas Genet Cytogenet Oncol Haematol. 1999-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1162/t(1
