t(12;13)(p12;q12-14) ETV6/CDX2

2000-04-01   Nick CP Cross 

1.Wessex Regional Genetics Laboratory Salisbury District Hospital Salisbury, SP2 8BJ, UK

Clinics and Pathology


chronic myelogenous leukemia (CML) in transformation, myelodysplastic syndrome (MDS), acute non lymphocytic leukemai (AML), B and T- acute lymphocytic leukemias (ALL)

Genes Involved and Proteins

Gene name
ETV6 (ets variant 6)
Gene name
CDX2 (caudal-related homeobox 2)

Highly cited references

Pubmed IDYearTitleCitations
147186722004Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.34
99208521999Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12).20


Pubmed IDLast YearTitleAuthors
99208521999Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12).Chase A et al
103798681999Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia.Coignet LJ et al
92345841997Duplication of the der(13)t(12;13)(p13;q14) in chronic myelomonocytic leukemia.Fugazza G et al
94142891998Molecular delineation of 13q deletion boundaries in 20 patients with myeloid malignancies.La Starza R et al
20188381991New recurring chromosomal translocations in childhood acute lymphoblastic leukemia.Raimondi SC et al
95046351998Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12.Streubel B et al
79543181994Reciprocal translocation t(12;13)(p13;q14) in acute nonlymphoblastic leukemia: report and cytogenetic analysis of two cases.Tosi S et al
94547711998Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies.Wlodarska I et al


Fusion gene

ETV6/CDX2 ETV6 (12p13.2) CDX2 (13q12.2) M t(12;13)(p13;q12)|ETV6/CDX2 ETV6 (12p13.2) CDX2 (13q12.2) TIC


Nick CP Cross

t(12;13)(p12;q12-14) ETV6/CDX2

Atlas Genet Cytogenet Oncol Haematol. 2000-04-01

Online version: http://atlasgeneticsoncology.org/haematological/1204/t(12;13)(p12;q12-14)