t(1;8)(p22-p32;q22-q23)
2008-02-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukaemia (AML); non-Hodgkin lymphoma (NHL)
Note
The disease is likely to be heterogeneous, with different phenotypes (AML and NHL) for a given breakpoint (1p31 and 8q22), and possibly similar or different breakpoints in different AML cases.
Epidemiology
3 cases of AML: two of which were M2 cases (ages and sex were: 84 years/F; 40 years/ M; ?/?); the NHL case was 71 year-old male patient with a small cleaved cell follicular lymphoma
Genes Involved and Proteins
Note
Genes involved are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 6850608 | 1983 | Nonrandom chromosome abnormalities in lymphoma. | Bloomfield CD et al |
| 8908165 | 1996 | Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis. | Calabrese G et al |
| 11165315 | 2001 | Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. | Kerndrup GB et al |
| 2353967 | 1990 | Acute megakaryocytic leukemia. | Moertel CL et al |
| 11746988 | 2002 | Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. | Van Limbergen H et al |
Citation
Jean-Loup Huret
t(1;8)(p22-p32;q22-q23)
Atlas Genet Cytogenet Oncol Haematol. 2008-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1207/t(1
