t(1;16)(q11;q11)
2002-05-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
only 3 cases of myelodysplastic syndrome (MDS) and 1 case of non Hodgkin lymphoma (NHL). The 3 MDS cases were: 2 refractory anemia with excess of blasts (RAEB), evolving towards M2 acute myeloid leukemia (AML), and 1 refractory anemia with ringed sideroblasts (RARS) evolving towards M6-AML; the NHL case was a VIH-associated large cell NHL.
Epidemiology
the MDS cases were aged 59-74 yrs, the NHL patient was 29 yr old; sex ratio: 4M/0F.
Prognosis
survival in MDS: 13 mths, 15 mths+, 54 mths+; death of an unrelated cause in the NHL.
Cytogenetics
Cytogenetics morphological
presents as a der(16) t(1;16) in the 3 MDS
Additional anomalies
sole anomaly in 1 MDS, accompanied with +8 in the 2 other MDS cases; the NHL case exhibited a t(8;14)(q24;q11) and a complex caryotype; i.e. probable primary anomaly in MDS, secondary anomaly in the NHL case
Genes Involved and Proteins
Note
genes involved are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7786773 | 1995 | Der(16)t(1;16)(q11;q11) in myelodysplastic syndromes: a new non-random abnormality characterized by cytogenic and fluorescence in situ hybridization studies. | Mugneret F et al |
| 8630904 | 1995 | Centromeric instability of chromosome 1 resulting in multibranched chromosomes, telomeric fusions, and "jumping translocations" of 1q in a human immunodeficiency virus-related non-Hodgkin's lymphoma. | Sawyer JR et al |
Citation
Jean-Loup Huret
t(1;16)(q11;q11)
Atlas Genet Cytogenet Oncol Haematol. 2002-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1247/t(1
