t(1;2)(q12;q37) in acute leukemias
2014-11-01 Shen Yueyang , Shen Yueyang , Shen Yueyang Affiliation1.Cytogenetics Laboratory, Department of Pathology, Laboratory Medicine, Vancouver, BC, Canada. [email protected]
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Abstract
Review on t(1;2)(q12;q37), with data on clinics.
Clinics and Pathology
Disease
Acute leukemias
Phenotype stem cell origin
1 case of M0 acute myeloid leukemia (AML), 1 case of M4 AML, 1 case of M5 AML with monocytic/monoblastic differentiation and 1 case of L1 acute lymphoblastic leukemia (ALL).
Epidemiology
a 76 yr old female patient, a 81 yr old male patient, a 31 yr old male patient and a 69 yr old male patient (ALL). A t(1;2)(q12;q37 has also been found in myelodysplastic syndrome (RAEB), 2 multiple myeloma cases, and 2 hepatoblastoma cases.
Prognosis
Unknown
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10602418 | 1999 | Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations. | Busson-Le Coniat M et al |
| 3708160 | 1986 | Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes. | Jacobs RH et al |
| 11568011 | 2001 | Hypodiploidy is a major prognostic factor in multiple myeloma. | Smadja NV et al |
Summary
Note
Only a few cases reported to date, poorly known
G-band analysis - partial karyotype showing der(2)t(1;2)(q12;q37) Courtesy Drs. Tanya Gillan and Hŕ Bruyè, Vancouver General Hospital Cytogenetics Laboratory
Citation
Shen Yueyang ; Shen Yueyang ; Shen Yueyang
t(1;2)(q12;q37) in acute leukemias
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/haematological/1317/case-report-explorer/teaching-explorer/meetings/cancer-prone-explorer/
Historical Card
2000-02-01 t(1;2)(q12;q37) in acute leukemias by Jean-Loup Huret Affiliation
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
