t(4;16)(q26;p13) IL2/TNFRSF17
2006-03-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
T-cell lymphoma of the small intestine of low grade malignancy
Phenotype stem cell origin
CD3, CD4, TCR A-B phenotype.
Epidemiology
Only 1 case to date, a 28-year-old male patient.
Genes Involved and Proteins
Gene name
IL2 (interleukin 2)
Location
4q27
Dna rna description
6 exons
Protein description
Role in mediation of the immune system; member of the IL2 family of cytokines; binds to and signals through a receptor complex consisting of IL2Ralpha, IL2Rbeta, and gamma chain; T-cell growth factor.
Gene name
TNFRSF17 (tumor necrosis factor receptor superfamily, member 17)
Location
16p13.13
Dna rna description
3 exons
Protein description
Role in mediation of the immune system; member of the TNF-receptor superfamily; binds to TNFSF13B/BAFF/BLys and TNFSF13/APRIL; promotes B-cell survival.
Result of the Chromosomal Anomaly
Description
5 IL2 - 3 TNFRSF17; breakpoint in intron 3 of IL2.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8313332 | 1994 | Extensive small intestinal T-cell lymphoma of low-grade malignancy associated with a new chromosomal translocation. | Carbonnel F et al |
| 1396583 | 1992 | A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. | Laâbi Y et al |
Summary
Fusion gene
IL2/TNFRSF17 IL2 (4q27) TNFRSF17 (16p13.13) M|IL2/TNFRSF17 IL2 (4q27) TNFRSF17 (16p13.13) M t(4;16)(q27;p13)
Citation
Jean-Loup Huret
t(4;16)(q26;p13) IL2/TNFRSF17
Atlas Genet Cytogenet Oncol Haematol. 2006-03-01
Online version: http://atlasgeneticsoncology.org/haematological/1358/t(4
