t(8;12)(q22;q13) HMGA2/?

2005-05-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


myeloproliferative/myelodysplastic syndrome (MPD/MDS)


only 1 case to date: a 53yr old female patient with atypical chronic myelogenous leukemia (aCML) (with no BCR-ABL rearrangement)


sole anomaly in a subclone; accompanied with del(13q) in another one

Genes Involved and Proteins

Gene name
HMGA2 (high mobility group AT-hook 2)
Protein description
probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes

Result of the Chromosomal Anomaly


ectopic expression of HMGA2

Highly cited references

Pubmed IDYearTitleCitations
334810142022Long non-coding RNA DANCR accelerates colorectal cancer progression via regulating the miR-185-5p/HMGA2 axis.5
346375482022Critical role of the high mobility group A proteins in hematological malignancies.4
343244562022HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology.3
352132732022The anti-cancer role of microRNA-143 in papillary thyroid carcinoma by targeting high mobility group AT-hook 2.2
345933182022Circ-RPPH1 knockdown retards breast cancer progression via miR-328-3p-mediated suppression of HMGA2.2
352123752022AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes.2
356871192022Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry-Mass Spectrometry.1
354664712022LncRNA SNHG1 promotes renal cell carcinoma progression through regulation of HMGA2 via sponging miR-103a.1
353660532022Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells.1
352381182022Development and validation of an RNA sequencing panel for gene fusions in soft tissue sarcoma.1
354091732022Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma.1
352930502022Insulin-like growth factor 2 mRNA-binding protein 2-regulated alternative splicing of nuclear factor 1 C-type causes excessive granulosa cell proliferation in polycystic ovary syndrome.1
350678512022The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell.1
352513192022Overview of systemic therapy options in liposarcoma, with a focus on the activity of selinexor, a selective inhibitor of nuclear export in dedifferentiated liposarcoma.1
351188892022Effects of HMGA2 gene silencing on cell cycle and apoptosis in the metastatic renal carcinoma cell line ACHN.1
350809882022SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis.1
350310542022Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation.1
350239572022MiR-195-3p is a Novel Prognostic Biomarker Associated with Immune Infiltrates of Lung Adenocarcinoma.1
344031592022Breast hamartoma: reassessment of an under-recognised breast lesion.1
352652542022HMGA2 Immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of PLAG1 and HMGA2 in 25 cases.1
352005322022Development of Primary Monolayer Cell Model and Organotypic Model of Uterine Leiomyoma.1
360264432022Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.0
359856842022Fusion of High Mobility Group AT-hook 2 Gene (HMGA2) With the Chromosome 12 Open Reading Frame 42 Gene (C12orf42) in an Aggressive Angiomyxoma With del(12)(q14q23) as the Sole Cytogenetic Anomaly.0
359663352022HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-κB Signaling Pathway.0
359465682022Identification of exosomal circRNA CD226 as a potent driver of nonsmall cell lung cancer through miR-1224-3p/high mobility group AT-hook 2 axis.0
359276402022High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling pathway.0
359187132022Hmga2 protein loss alters nuclear envelope and 3D chromatin structure.0
358489692022Drug response biomarkers of Pien Tze Huang treatment for hepatic fibrosis induced by carbon tetrachloride.0
354824752022Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis.0
359616562022Histological and molecular analysis of cellular leiomyoma with sclerosis: linked to HMGA2 overexpression.0
359036962022Nitrogen Metabolism Disorder Accelerates Occurrence and Development of Lung Adenocarcinoma: A Bioinformatic Analysis and In Vitro Experiments.0
3582244820223'RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1.0
358115002022KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer.0
358104572022Clinical implications and biological features of a novel postoperative recurrent HCC classification: A multi-centre study.0
357323192022Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case.0
356878722022Exploring the Conformations and Binding Location of HMGA2·DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass Spectrometry.0
355898282022Shared genetic architectures of subjective well-being in East Asian and European ancestry populations.0
360095172022Chromosome Translocations, Gene Fusions, and Their Molecular Consequences in Pleomorphic Salivary Gland Adenomas.0
359856832022Presence of a t(12;18)(q14;q21) Chromosome Translocation and Fusion of the Genes for High-mobility Group AT-Hook 2 (HMGA2) and WNT Inhibitory Factor 1 (WIF1) in Infrapatellar Fat Pad Cells from a Patient With Hoffa's Disease.0
358404242022Retraction notice to "Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis" [Life Sci. 249 (2020) 117480].0
357972432022HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.0
357641012022HMGA2-Snai2 axis regulates tumorigenicity and stemness of head and neck squamous cell carcinoma.0
353674242022The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway.0
352670842022The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls.0
358848472022Stem Cell Growth and Differentiation in Organ Culture: New Insights for Uterine Fibroid Treatment.0
358370272022lncRNA HIT000218960 enhances resistance to 5-fluorouracil by promoting HMGA2 and activating the AKT/mTOR/P70S6K pathway in gastric cancer cells.0
358059372022Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis.0
356906442022Xanthogranulomatous epithelial tumors and keratin-positive giant cell-rich soft tissue tumors: two aspects of a single entity with frequent HMGA2-NCOR2 fusions.0
358711662022Exosomal circPABPC1 promotes colorectal cancer liver metastases by regulating HMGA2 in the nucleus and BMP4/ADAM19 in the cytoplasm.0
358385592022Statement of Retraction: microRNA-98 protects sepsis mice from cardiac dysfunction, liver and lung injury by negatively regulating HMGA2 through inhibiting NF-κB signaling pathway.0
356798982022Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2.0
355520872022Circ_0000514 promotes the malignant biological behaviors of non-small cell lung cancer cells by modulating miR-330-5p and HMGA2.0
356816042022Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma.0
356647822022Molecular Landscape and Prognostic Biomarker Analysis of Advanced Pancreatic Cancer and Predictors of Treatment Efficacy of AG Chemotherapy.0
356630652022Diagnosis of an extremely rare case of malignant adenomyoepithelioma in pleomorphic adenoma: A case report.0
355628072022Microdeletions in 1q21 and 8q12.1 depict two additional molecular subgroups of Silver-Russell syndrome like phenotypes.0
354461832022Effects of prolonged treatment of TGF-βR inhibitor SB431542 on radiation-induced signaling in breast cancer cells.0
353889732022Expression and Clinical Significance of High-Mobility Group AT-hook 2 (HMGA2) in Osteosarcoma.0
353021712022TRIB2 regulates the expression of miR‑33a‑5p through the ERK/c‑Fos pathway to affect the imatinib resistance of chronic myeloid leukemia cells.0
350001952022CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2.0
357649192022Along the Bos taurus genome, uncover candidate imprinting control regions.0
357646382022Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency.0
357351832022Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management.0
357065082022Effect and Mechanism of lncRNA CERS6-AS1 on the Biological Behavior of Prostate Cancer Cell.0
354683382022Mechanisms of cancer stem cells drug resistance and the pivotal role of HMGA2.0
353972542022t(10;12)(q24;q15): A new cytogenetic marker in hematological malignancies.0
353245282022Dexmedetomidine disrupts esophagus cancer tumorigenesis by modulating circ_0003340/miR-198/HMGA2 axis.0
354399512022Effects of HMGA2 on the epithelial-mesenchymal transition-related genes in ACHN renal cell carcinoma cells-derived xenografts in nude mice.0
354282612022LINC00922 acts as a novel oncogene in gastric cancer.0
354092892022MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53.0
352565112022Sex Influences Age-Related Changes in Natural Antibodies and CD5+ B-1 Cells.0
358134772022NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation.0
356858322022Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer.0
356654022022A case report of scrotal lipoma and review of lipoma pathogenesis.0
356352232022Diagnostic Challenges and Pitfalls of Mammary Pleomorphic Adenoma Illustrated by a Case Report.0
356172142022Large scale across-breed genome-wide association study reveals a variant in HMGA2 associated with inguinal cryptorchidism risk in dogs.0
355996172022Effect of miR-663 on atherosclerosis by regulating the proliferation of vascular smooth muscle cells in lipid plaques.0
355716892022Study on the Role and Mechanism of LncRNA ZFasL in Renal Carcinoma.0
355028852022Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma.0
354883742022Regulatory Effect of let-7f Transfection in Non-Small Cell Lung Cancer on its Candidate Target Genes.0
336273752022Epithelial-mesenchymal transition and cancer stem cell interactions in breast phyllodes tumours: immunohistochemical evaluation of EZH2, EZR, HMGA2, CD24 and CD44 in correlation with outcome analysis.0
354011122022Micro-RNA let-7a-5p Derived From Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes the Regrowth of Neurons in Spinal-Cord-Injured Rats by Targeting the HMGA2/SMAD2 Axis.0
353787832022Erratum: Long Intergenic Non-Coding RNA 01121 Promotes Breast Cancer Cell Proliferation, Migration, and Invasion via the miR-150-5p/HMGA2 Axis [Corrigendum].0
353538972022Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death.0
352641082022EZH2 mitigates the cardioprotective effects of mesenchymal stem cell-secreted exosomes against infarction via HMGA2-mediated PI3K/AKT signaling.0
351314732022Signatures of selection in Nelore cattle revealed by whole-genome sequencing data.0
354501972022Cytogenomic Characterization of Giant Ring or Rod Marker Chromosome in Four Cases of Well-Differentiated and Dedifferentiated Liposarcoma.0
354002822022Circle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis.0
353881722022Exosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis.0
353227352022Hyaluronan-mediated motility receptor antisense RNA 1 promotes hepatitis B virus-related hepatocellular carcinoma progression by regulating miR-627-3p/High Mobility Group AT-hook 2 axis.0
352311052022Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice.0
356203352022Downregulation of HMGA2 by Small Interfering RNA Affects the Survival, Migration, and Apoptosis of Prostate Cancer Cell Line.0
354543382022Prognostic Gene Predictors of Gestational Diabetes in Endometrium and Follicular Fluid of Women after Infertility.0
352126092022Long non-coding RNA HIF1A-AS2 modulates the proliferation, migration, and phenotypic switch of aortic smooth muscle cells in aortic dissection via sponging microRNA-33b.0
351815862022Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone.0
351158362022Long Non-Coding RNA LINC00466 Knockdown Inhibits Tongue Squamous Cell Carcinoma Malignancy by Targeting microRNA-493/HMGA2 [Retraction].0
350925012022The analysis of N6-methyladenosine regulators impacting the immune infiltration in clear cell renal cell carcinoma.0
349970062022Comparative proteomic analysis of nuclear and cytoplasmic compartments in human cardiac progenitor cells.0
349868552022Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma.0
349735322022High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.0


Pubmed IDLast YearTitleAuthors
156189632005Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.Odero MD et al


Jean-Loup Huret

t(8;12)(q22;q13) HMGA2/?

Atlas Genet Cytogenet Oncol Haematol. 2005-05-01

Online version: http://atlasgeneticsoncology.org/haematological/1389/t(8;12)(q22;q13)

External Links