t(12;14)(q13;q31) HMGA2/?

2005-05-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

myelodysplastic syndrome (MDS)

Epidemiology

only 1 case to date: a 63 yr old male patient with RAEB2

Cytogenetics

sole anomaly in this patient

Prognosis

The patient died 6 mths after diagnosis

Genes Involved and Proteins

Gene name
HMGA2 (high mobility group AT-hook 2)
Location
12q14.3
Protein description
probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes

Result of the Chromosomal Anomaly

Description

ectopic expression of HMGA2

Highly cited references

Pubmed IDYearTitleCitations
323657122020High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia.194
336684532021HMGA2 as a Critical Regulator in Cancer Development.191
390857032024Decoding high mobility group A2 protein expression regulation and implications in human cancers.162
324661622020The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.156
383617842024HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition.147
387530812024The emerging role and mechanism of HMGA2 in breast cancer.143
330691032021Emerging roles for HMGA2 in colorectal cancer.115
368356562023Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.95
378280102023HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation.93
337497222021Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells.90
249149482014Generation and characterisation of a canine EGFP-HMGA2 prostate cancer in vitro model.85
328980132020High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis.78
383040372023HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis.75
385168872024Characterization of HMGA2 variants expands the spectrum of Silver-Russell syndrome.74
271020022016The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.73
371137832023Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells.72
331398122020Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.72
292967432017Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms.64
374459422023Unraveling the Roles of miR-204-5p and HMGA2 in Papillary Thyroid Cancer Tumorigenesis.62
302282962018Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance.59
388118512024Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions.58
316196852019N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.57
359187132022Hmga2 protein loss alters nuclear envelope and 3D chromatin structure.57
255751392015The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity.56
272592532016HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells.56
385720922024Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis.55
363093522022Fusion of the HMGA2 and BNC2 Genes in Uterine Leiomyoma With t(9;12)(p22;q14).54
246615622014Hmga2 is required for canonical WNT signaling during lung development.52
324893282020Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells.50
357972432022HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.50
349762232022HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment.49
285228322017The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.49
288147522017Oncofetal HMGA2 effectively curbs unconstrained (+) and (-) DNA supercoiling.48
384931652024HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells.47
353407772022HMGA2: A Biomarker in Gynecologic Neoplasia.47
253367372014Hmga2 regulates self-renewal of retinal progenitors.46
388459722024HMGA2 promotes resistance against paclitaxel by targeting the p53 signaling pathway in colorectal cancer cells.45
291097852017Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer.45
247289592014Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.45
287525302017HMGA2 regulates lung cancer proliferation and metastasis.44
348781162022Hmga2 deficiency is associated with allometric growth retardation, infertility, and behavioral abnormalities in mice.44
353889732022Expression and Clinical Significance of High-Mobility Group AT-hook 2 (HMGA2) in Osteosarcoma.44
333079622021HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway.44
237225452013HMGA2 is a driver of tumor metastasis.41
327193452020HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma.40
346803492021HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer.39
297335212018HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction.39
333155042020The pro-migration and anti-apoptosis effects of HMGA2 in HUVECs stimulated by hypoxia.38
332373282021HMGA2-induced epithelial-mesenchymal transition is reversed by let-7d in intrauterine adhesions.37
361808902022Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer.37
339862482021A KLF4/PiHL/EZH2/HMGA2 regulatory axis and its function in promoting oxaliplatin-resistance of colorectal cancer.36
328681052020HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma.35
284157892017Hmga2 translocation induced in skin tumorigenesis.35
394472782024HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells.34
341159202021CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.33
359663352022HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-κB Signaling Pathway.32
384496302024HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression.25
381126162023LncRNA HAGLROS contribute to papillary thyroid cancer progression by modulating miR-206/HMGA2 expression.25
283568452015HMGA2 Expression in Renal Carcinoma and its Clinical Significance.22
327804942020Biomarker function of HMGA2 in ultraviolet-induced skin cancer development.21
388401872024Pathogenic sequence variant and microdeletion affecting HMGA2 in Silver-Russell syndrome: case reports and literature review.10
269014962016Hmga2 is dispensable for cutaneous squamous cell carcinoma.8
314321512019Oncological role of HMGA2 (Review).0
236862602013HMGA2 and high-grade serous ovarian carcinoma.0
303055102018[The role of HMGA2 in myeloproliferative neoplasms].0
369315422023HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response.0
396800212025HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.0
390894762024Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights.0
392227522024CircRNAs as upstream regulators of miRNA//HMGA2 axis in human cancer.0
376983442024A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2.0
345472562021HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.0
392784262024Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma.0
195285022009Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases.0
361163522022HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.0
349735322022High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.0
379975022023LINC02454 promotes thyroid carcinoma progression via upregulating HMGA2 through CREB1.0
325922172020An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation.0
357641012022HMGA2-Snai2 axis regulates tumorigenicity and stemness of head and neck squamous cell carcinoma.0
337447652021Methylation-dependent SUMOylation of the architectural transcription factor HMGA2.0
115769962001Role of the high mobility group A proteins in human lipomas.0
287108222017Prevalence and significance of HMGA2 expression in oesophageal adenocarcinoma.0
368255042023Green Tea Epigallocatechin Gallate Inhibits Preadipocyte Growth via the microRNA-let-7a/HMGA2 Signaling Pathway.0
269660682016HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ.0
285103662017HMGA2 plays an important role in Cr (VI)-induced autophagy.0
365640762022HMGA2 Synergizes with EZH2 to Mediate Epithelial Cell Inflammation and Apoptosis in Septic Lung Dysfunction.0
344819052021A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.0
324218272020HMGA2 Variants in Silver-Russell Syndrome: Homozygous and Heterozygous Occurrence.0
308252042019HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy.0
390326832024HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration.0
169690982006Critical role of the HMGA2 gene in pituitary adenomas.0
353674242022The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway.0
263193922016Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.0
136790312003Hmga2 promoter analysis in transgenic mice.0
301758542018HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53.0
268067042016Hmga2 is required for neural crest cell specification in Xenopus laevis.0
301372142019HMGA2 is regulated by LIN28 and BRCA1 in human placental cells.0
372681622023HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression.0
309990052019Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors.0
331114252021Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma.0
300175372018HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
156189632005Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.Odero MD et al

Citation

Jean-Loup Huret

t(12;14)(q13;q31) HMGA2/?

Atlas Genet Cytogenet Oncol Haematol. 2005-05-01

Online version: http://atlasgeneticsoncology.org/haematological/1392/t(12;14)(q13;q31)