t(2;9)(p11;p13) PAX5/?
2005-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
pre B acute lymphocytic leukemia (ALL)
Epidemiology
only one case to date
Cytogenetics
sole anomaly
Genes
PAX5 was rearranged
Genes Involved and Proteins
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36077495 | 2022 | The Pleiotropy of PAX5 Gene Products and Function. | 198 |
| 25123279 | 2014 | The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. | 138 |
| 38318177 | 2024 | EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms. | 136 |
| 39183332 | 2024 | Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers. | 100 |
| 35947077 | 2022 | Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. | 96 |
| 38168280 | 2023 | Understanding the role of Pax5 in development of taxane-resistant neuroendocrine like prostate cancers. | 96 |
| 38926764 | 2024 | Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop. | 87 |
| 36387144 | 2022 | PAX5 alterations in B-cell acute lymphoblastic leukemia. | 86 |
| 34301800 | 2021 | Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. | 86 |
| 37335685 | 2023 | PAX5 fusion genes in acute lymphoblastic leukemia: A literature review. | 81 |
| 37725138 | 2023 | Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development. | 77 |
| 37620322 | 2023 | Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice. | 74 |
| 33004416 | 2020 | EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. | 74 |
| 30216339 | 2018 | Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations. | 73 |
| 36656641 | 2023 | Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets. | 70 |
| 35156727 | 2022 | The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation. | 69 |
| 33154497 | 2020 | Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis. | 66 |
| 30643249 | 2019 | PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. | 65 |
| 36516256 | 2022 | PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia. | 65 |
| 38866979 | 2024 | The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence. | 63 |
| 25855603 | 2015 | PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia. | 62 |
| 39424985 | 2024 | A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5. | 59 |
| 36064939 | 2022 | The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa. | 52 |
| 31941781 | 2020 | B Cell-Specific Transcription Activator PAX5 Recruits p300 To Support EBNA1-Driven Transcription. | 52 |
| 37221950 | 2023 | PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1. | 49 |
| 39256480 | 2024 | Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5. | 48 |
| 29713018 | 2018 | A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells. | 48 |
| 39096792 | 2024 | PAX5 functions as a tumor suppressor by RB-E2F-mediated cell cycle arrest in Kaposi sarcoma-associated herpesvirus-infected primary effusion lymphoma. | 47 |
| 33619557 | 2021 | EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. | 46 |
| 21357426 | 2011 | Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity. | 45 |
| 37403081 | 2023 | PAX5-miR-142 feedback loop promotes breast cancer proliferation by regulating DNMT1 and ZEB1. | 44 |
| 34824296 | 2021 | Pax5 mediates the transcriptional activation of the CD81 gene. | 43 |
| 28219927 | 2017 | Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia. | 43 |
| 37184294 | 2023 | BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5. | 41 |
| 21765475 | 2012 | Dominant-negative mechanism of leukemogenic PAX5 fusions. | 41 |
| 24858437 | 2014 | Nasopharyngeal tonsils (adenoids) contain extrathymic corticothymocytes. | 41 |
| 35985167 | 2022 | PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. | 40 |
| 28192788 | 2017 | Metabolic gatekeeper function of B-lymphoid transcription factors. | 38 |
| 38348125 | 2024 | Paired Box 5 (PAX5) Gene Has Diagnostic and Prognostic Potential in Nasopharyngeal Carcinoma. | 38 |
| 38776375 | 2024 | SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. | 37 |
| 33672551 | 2021 | Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1. | 37 |
| 30257940 | 2018 | PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice. | 37 |
| 7777574 | 1995 | Deregulated expression of PAX5 in medulloblastoma. | 30 |
| 27748274 | 2016 | Level of PAX5 in differential diagnosis of non-Hodgkin's lymphoma. | 29 |
| 35094443 | 2022 | Delineation of a novel neurodevelopmental syndrome associated with PAX5 haploinsufficiency. | 27 |
| 35264043 | 2022 | Pax5 and CD3 immunophenotyping of lymphoma in 2 central bearded dragons. | 19 |
| 34531928 | 2006 | dic(7;9)(p11-13;p11). | 16 |
| 35467057 | 2022 | PAX5 alterations in an infant case of KMT2A-rearranged leukemia with lineage switch. | 15 |
| 39256601 | 2024 | Diverse mechanisms of leukemogenesis associated with PAX5 germline mutation. | 15 |
| 22578776 | 2012 | PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia. | 8 |
| 35460405 | 2022 | IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas. | 6 |
| 39179932 | 2024 | Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development. | 0 |
| 17717432 | 2007 | Diagnostic uses of Pax5 immunohistochemistry. | 0 |
| 21970955 | 2011 | Pax5: a master regulator of B cell development and leukemogenesis. | 0 |
| 18293359 | 2008 | Losing B cell identity. | 0 |
| 25428382 | 2015 | The role of Pax5 in leukemia: diagnosis and prognosis significance. | 0 |
| 26626503 | 2016 | GEMMs addressing Pax5 loss-of-function in childhood pB-ALL. | 0 |
| 18240995 | 2008 | PAX5 and B-cell neoplasms: transformation through presentation. | 0 |
| 16918686 | 2006 | Pax5--a critical inhibitor of plasma cell fate. | 0 |
| 10712946 | 2000 | Lineage commitment in lymphopoiesis. | 0 |
| 17102626 | 2006 | Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation. | 0 |
| 11342298 | 2001 | Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis. | 0 |
| 17440452 | 2007 | Pax5: the guardian of B cell identity and function. | 0 |
| 34872475 | 2022 | PAX5 Haploinsufficiency Induces Low T Cell Infiltration in the Cancer Microenvironment via Reduced Chemokines. | 0 |
| 17998914 | 2008 | The regulation of the B-cell gene expression programme by Pax5. | 0 |
| 16464566 | 2006 | Transcription factors drive B cell development. | 0 |
| 36484735 | 2023 | FOXO1 and PAX5 Rearrangement in Alveolar Rhabdomyosarcoma in Saudi Pediatric Patients. | 0 |
| 36351649 | 2022 | [PAX5-positive plasma cell leukemia presenting as lymphocytosis]. | 0 |
| 12366685 | 2002 | Stability and plasticity of wild-type and Pax5-deficient precursor B cells. | 0 |
| 12021490 | 2002 | Plasticity of Pax-5(-/-) pre-B I cells. | 0 |
| 10607584 | 1999 | B-cell commitment: Pax5 is the deciding factor. | 0 |
| 21707507 | 2011 | Coordinated expression of Pax-5 and FAK1 in metastasis. | 0 |
| 24435167 | 2014 | Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development. | 0 |
| 37149540 | 2023 | EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity. | 0 |
| 12008032 | 2002 | In vitro and in vivo plasticity of Pax5-deficient pre-B I cells. | 0 |
| 21217775 | 2011 | PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. | 0 |
| 19641453 | 2009 | PAX5 expression in rhabdomyosarcoma. | 0 |
| 10784387 | 2000 | The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma. | 0 |
| 39592470 | 2024 | Recurrent PAX5::ZCCHC7 rearrangement in B-cell acute lymphoblastic leukemia. | 0 |
| 34425470 | 2021 | PAX5 haploinsufficiency induced CD8+ T cells dysfunction or exhaustion by high expression of immune inhibitory-related molecules. | 0 |
| 15201612 | 2004 | The origins of osteoclasts. | 0 |
| 37126184 | 2023 | PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma. | 0 |
| 29134420 | 2018 | Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice. | 0 |
| 22127921 | 2011 | The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease. | 0 |
| 27623204 | 2016 | Expression of SOX11, PAX5, TTF-1 and ISL-1 in medulloblastoma. | 0 |
| 26115422 | 2015 | PAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia. | 0 |
| 39097885 | 2024 | Diagnostic efficacy of SEPT9 and PAX5 gene methylation in gastrointestinal cancer and precancerous lesions. | 0 |
| 27122187 | 2016 | PAX5 interacts with RIP2 to promote NF-κB activation and drug-resistance in B-lymphoproliferative disorders. | 0 |
| 17663980 | 2007 | "Hands-on" regulation of B cell development by the transcription factor Pax5. | 0 |
| 10430025 | 1999 | Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? | 0 |
| 15967678 | 2005 | Deficient B lymphopoiesis in murine senescence: potential roles for dysregulation of E2A, Pax-5, and STAT5. | 0 |
| 35926290 | 2022 | The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma. | 0 |
| 38189777 | 2024 | A PAX5 P80R pediatric B acute lymphoblastic leukemia with monocytic lineage switch at diagnosis: Deciphering classification ambiguity. | 0 |
| 11232287 | 1999 | Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene. | 0 |
| 9442394 | 1997 | Essential functions of Pax-5 (BSAP) in pro-B cell development. | 0 |
| 35902733 | 2022 | Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants. | 0 |
| 29453973 | 2018 | PAX5 haploinsufficiency induce cancer cell dormancy in Raji cells. | 0 |
| 17016584 | 2006 | Overexpression of PAX5 in oral carcinogenesis. | 0 |
| 36730754 | 2023 | PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway. | 0 |
| 36480208 | 2023 | Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12399965 | 2002 | The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia. | Lu XY et al |
Summary
t(2;9)(p11;p13) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.
Citation
Jean-Loup Huret
t(2;9)(p11;p13) PAX5/?
Atlas Genet Cytogenet Oncol Haematol. 2005-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1404/t(2
