KMT2A (myeloid/lymphoid or mixed lineage leukemia)

11q23.3

KMT2A (HGNC official name!) is better known as MLL.

3969 amino acids; Transcriptional regulatory factor. MLL is known to be associated with more than 30 proteins, including the core components of the SWI/SNF chromatin remodeling complex and the transcription complex TFIID. MLL binds promotors of HOX genes through acetylation and methylation of histones. MLL is a major regulator of hematopoesis and embryonic development, through regulation of HOX genes expression regulation (HOXA9 in particular). , Cytokinesis is the final stage of cell division.There is an abscission checkpoint (also termed "NoCut") which depends on AURKB (17p13.1). The membrane abscission is mediated by the ESCRT machinery through the activity of the VPS4 proteins (VPS4A, 16q22.1 and VPS4B, 18q21.33). VPS4 localizes transiently to the midbody ring towards the end of cytokinesis. ZFYVE19 and CHMP4C (8q21.13) bind VPS4 following checkpoint, and AURKB sustains this ternary complex. Termination of AURKB-mediated signalling results in dephosphorylation of CHMP4C, followed by dislocation of the ternary complex, and release of VPS4, which is then activated to complete abscission (Thoresen et al., 2014).

ZFYVE19 (zinc finger FYVE-type containing 19)

15q15.1

ZFYVE19 is also known as ANCHR (for Abscission/NoCut Checkpoint Regulator), or MPFYVE (for MLL Partner Containing FYVE Domain).

471 amino acids. ZFYVE19 contains a Zinc finger FYVE-type (amino acids 74-133), MIM1 domains (type-1 microtubule interacting and transport (MIT) domain-interacting motifs MIMs, to mediate interaction between ESCRT-III proteins and the VPS4 MIT domain): MIM1-A (aa 174-187) and MIM1-B (aa 326-339), and a B-box domain in C-term.