t(1;21)(q21;q22) RUNX1/ZNF687
2007-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukaemia (AML)
Epidemiology
only one case to date, a 1 year old boy with M1 AML
Prognosis
no data
Genes Involved and Proteins
Gene name
ZNF687 (zinc finger protein 687)
Location
1q21.3
Protein description
10 zinc fingers; krueppel C2H2-type zinc-finger protein; transcription factor
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Protein description
Transcription factor (activator) for various hematopoietic-specific genes, which experssion is limited to hematopoetic stem cells, and endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5 PyGPyGGTPy 3 of promotors and enhancers
Result of the Chromosomal Anomaly
Description
5 RUNX1- 3 ZNF687
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16858696 | 2006 | Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. | Nguyen TT et al |
Summary
Fusion gene
RUNX1/ZNF687 RUNX1 (21q22.12) ZNF687 (1q21.3) M t(1;21)(q21;q22)|RUNX1/ZNF687 RUNX1 (21q22.12) ZNF687 (1q21.3) TIC
q21;q22) t(1;21)(q21;q22) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.
Citation
Jean-Loup Huret
t(1;21)(q21;q22) RUNX1/ZNF687
Atlas Genet Cytogenet Oncol Haematol. 2007-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1446/t(1
