t(6;14)(p22;q32) IGH/ID4
2008-04-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
B-cell acute lymphoblastic leukaemia (B-ALL)
Phenotype stem cell origin
Pre-B ALL: CD10+ in 14 of 15 cases, CD19+ probably in the remaining case.
Epidemiology
15 cases available: 9 male and 6 female patients; mediane age was 16 years (range: 6 - 48 years).
Clinics
Complete remission was obtained in 15 of 15 cases.
Prognosis
Prognosis looks fair (see survival curve).
Genes Involved and Proteins
Note
Gene name
ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)
Location
6p22.3
Protein description
Member of the ID gene family : "Inhibitors of DNA binding". They are transcription factors which act as transcription inhibitory proteins. They are basic helix-loop-helix (bHLH) proteins which contain the bHLH dimerization domain, but lack the DNA binding domain. They form heterodimers with other bHLH proteins and inhibit them. ID4 may play an important suppressive role in tumor progression, and its silencing by hypermethylation favours tumorogenesis
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33
Result of the Chromosomal Anomaly
Description
No hybrid gene, but juxtaposition of ID4 to the IGH enhancer, leading to ID4 overexpression.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15882580 | 2005 | Id4 is required for the correct timing of neural differentiation. | Bedford L et al |
| 12969807 | 2003 | Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. | Bellido M et al |
| 14534543 | 2003 | Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. | Chan AS et al |
| 17510533 | 2007 | Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma. | Hagiwara K et al |
| 16018821 | 2005 | Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. | Liang Y et al |
| 10611221 | 2000 | Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. | Massari ME et al |
| 16682435 | 2006 | Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. | Peddada S et al |
| 11840323 | 2001 | The regulation and function of the Id proteins in lymphocyte development. | Rivera R et al |
| 16582598 | 2006 | Tumoral expression of BRCA1, estrogen receptor alpha and ID4 protein in patients with sporadic breast cancer. | Roldán G et al |
| 17940204 | 2008 | t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). | Russell LJ et al |
| 15897910 | 2005 | Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer. | Umetani N et al |
| 15569977 | 2004 | Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. | Umetani N et al |
| 15876350 | 2005 | Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer. | Wu Q et al |
| 15723065 | 2005 | Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. | Yu L et al |
| 15469968 | 2004 | Id4 regulates neural progenitor proliferation and differentiation in vivo. | Yun K et al |
| 16867866 | 2006 | Id4 messenger RNA and estrogen receptor expression: inverse correlation in human normal breast epithelium and carcinoma. | de Candia P et al |
Summary
Fusion gene
IGH/ID4 IGH (14q32.33) ID4 (6p22.3) M t(6;14)(p22;q32)
t(6;14)(p22;q32) G-banding and FISH - Courtesy Dorothy Hung, Luke St-Heaps and Dale Wrigh, The Cytogenetics Department of Childrens Hospital at Westmead Sydney, Australia.
Citation
Jean-Loup Huret
t(6;14)(p22;q32) IGH/ID4
Atlas Genet Cytogenet Oncol Haematol. 2008-04-01
Online version: http://atlasgeneticsoncology.org/haematological/1480/t(6
