2008-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Myeloproliferative syndrome (MPD) and acute myeloid leukaemia (AML)

Phenotype stem cell origin

One case was a M2-AML, another case was a MPD associated with an AML, the third case was an AML not otherwise specified.


Only three cases available; two male and one female patients aged 62, 63, and 71 yrs.


Cytogenetics morphological

The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.

Additional anomalies

The three cases present with very similar cytogenetic profiles: major karyotypic anomalies were present in 3 out of 3 cases; -5/del(5q) was found in the three cases, and +8 and -14 were found in two cases each.

Genes Involved and Proteins

Genes involved are unknown.


Pubmed IDLast YearTitleAuthors
108659692000Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome.Mohr B et al
117469882002Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.Van Limbergen H et al
90903891997Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.Veldman T et al


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1484/t(7;14)(q21;q13)