Extremely rare i(X)(q10) occurs in male patients, only five cases have been reported in lymphoid malignancies, including acute lymphoblastic leukemia (ALL) (Bacher et al, 2009), diffuse large B-cell lymphoma (Itoyama et al, 2002, Gindina T., table 1, case #3) and follicular lymphoma (Dave t al, 1999; Donti et al., 1988).

Table 1. Reported cases with i(X)(q10).

Pts	Age, gender	Disease	Karyotype	Author
1	51, M	B-cell precursor ALL (relapse after CT)	46,Y,i(X)(q10),der(1)dup(1)(q32q21)t(1;17)(q42;q23),ins(7;8)(p21;p21;23),der(17)t(1;17)(q42 ;q23)[6]/46,XY[17]	Bacher et al, 2009
2	?, M	DLBCL	47-48,i(X)(q10),-Y,inv(1)(p32q21),del(2)(q13),hsr(3)(q27),add(4)(q35),del(4)(q31),-6,+7,der(11)t(5;11)(q13;q23),+13, t(14;18)(q32;q21),-15,-16,-17,+mar	Itoyama et al, 2002
3	60, M	DLBCL	67<3n>,Y,add(X)(p22),i(X)(q10),-2,del(2)(p21),-4,+7,+7,dic(7;7)(p22;p22),der(8)del(8)(p12)t(8;11)(q24;q13),+9,i(9)(p10), +12,der(12)t(3;12)(q13;p13),add(12)(p13),-13,+14,i(14)(q10),-15,-15,i(15)(q10),-16,add(17)(p11),add(18)(q23),-19, add(20)(q13),+21,i(21)(q10),-22,+mar [20] (Fig 1 and 2.)	Gindina T, own case
4	75, M	FL	47,XY,+i(X)(q10),t(1;11)(p36;q21),del(4)(q32),del(9)(q21),t(14;18)(q32;q21)[8]/46,XY[2]	Dave et al, 1999
5	?, M	FL	48,XY,+i(X)(q10),+i(X)(p10),add(1)(q?),+12,add(14)(q?)/48,Y,i(X)(q10),+i(X)(p10),add(1),t(2;8)(p12;q24),+12,add(14)	Donti et al, 1988

ALL: acute lymphoblastic leukemia; DLBCL: diffuse large B-cell lymphoma; FL: follicular lymphoma

Additional chromosome anomalies were observed in all five patients. Extra i(X)(q10) was present in 3 patients (Donti et al., 1988; Dave et al, 1999; Gindina et al, case #3). Associated in combination with other isochromosomes in 2 patients (Donti et al, 1988; Gindina, case #3). In all cases, i(X)(q10) is part of a complex karyotype. t(14;18)(q32;q21) was found in 2 cases: 1 FL case and 1 DLBCL (Dave et al, 1999; Itoyama et al, 2002).

The major consequence of this abnormality is loss of several genes on Xp and gain of several genes on Xq, that leads to genetic imbalance.